OBJECTIVES To assess the cost-effectiveness of alternative initial strategies in the management of uninvestigated dyspepsia in adult patients presenting to a primary care physician in Canada. METHODS Clinical decision-making was modeled based on outcomes data from the literature and expert opinion. Costs were obtained from official reimbursement lists, and a detailed microcosting analysis of ...

An increasing number of studies support a potential role for coccoid forms in Helicobacter pylori infection. Evidence for this was obtained through scanning microscopy, genetic analysis for virulence traits, examination of the presence and activity of key enzymes, and other methods. We studied the serum immunoglobulin G responses to coccoid H. pylori forms by enzyme-linked immunosorbent assay (...

background :   vaculating cytotoxic a ( vaca ) gene is one of the multiple helicobacter pylori genotypes that produce a cytotoxin protein (vaca).this gene is a major cause of chronic peptic ulcers and gastric cancer. the aim of this study was to determine the correlation between vaca gene with peptic ulcer disease (pud) and non-ulcer dyspepsia (nud). methods :    this was a case control study o...

Background: Helicobacter pylori infection is a common chronic human bacterial infection. Tripletherapy regimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole is commonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradication rate. The present study was designed to evaluated efficacy of low dose furazo...

We assessed the clonality of duodenal mucosal T cells in patients with celiac disease and controls. Fifteen adult patients were studied. Four patients had a complicated celiac disease, 3 did not respond to a gluten-free diet, and 2 had an ulcerative jejunitis (including 1 patient with nonresponsive celiac disease). Seven patients had an untreated celiac disease responsive to a gluten-free diet....

The identification of Helicobacter pylori-strain specific factors that correlate with clinical outcome has remained elusive. We investigated possible relationships between a group of H. pylori antigens and clinical outcome and compared an immunoblot assay kit (HelicoBlot, version 2.1 [HB 2.1]; Genelabs Diagnostics) with an established serological test, the high-molecular-weight cell-associated ...

We present draft genome sequences of 10 Helicobacter pylori clinical strains isolated from children. This will be important for future studies of comparative genomics in order to better understand the virulence determinants underlying peptic ulcer disease.

OBJECTIVE The evolution of views regarding the impact of psychosocial factors on peptic ulcer was traced by examining all articles related to the upper gastrointestinal tract published in Psychosomatic Medicine since its inception. METHODS Titles were retrieved using MEDLINE and by manually searching tables of contents for the years 1939 through 2000. The articles were classified by type and ...

The quantity of histamine entering gastric juice has been followed during standard intramuscular pentagastrin tests in 10 patients (six duodenal ulcer, one gastric ulcer and three nonulcer dyspepsia), and during standard insulin tests in three (all duodenal ulcer). Following pentagastrin, peak histamine output occurred from 0-15 min in six patients and from 15-30 min in two. Acid output peaks f...