The ability of guinea pigs to recognize poly-I,-lysine (PLL), and hapten conjugates of PLL (H-PLL) as antigens is under the control of a single autosomal dominant gene which we will refer to as the PLL gene (1-3). Responder animals carrying this gene form specific antihapten antibodies and display delayed hypersensitivity reactions after immunization with H-PLL conjugates such as 2,4-dinitrophe...

We investigated the antigenic requirements for restimulation of H-2- restricted cytolytic T lymphocytes (CTL) in vitro to determine whether H-2 I region-restricted helper T cells are required in these responses. In one set of experiments, we studied the in vitro response of (responder x nonresponder)F(1) female T cells to the male antigen H-Y. We chose to examine this response because it has be...

Initially, the rationale behind the use of echocardiography to assess mechanical synchrony seemed straightforward. Not all patients with left bundle-branch block (LBBB) have mechanical dyssynchrony, and this entity could be identified by measuring the contraction delay between different cardiac walls. It was hoped that better selection with echocardiography would minimize the nonresponder rate ...

INTRODUCTION Inhaled nitric oxide (INO) allows selective pulmonary vasodilation in acute respiratory distress syndrome and improves PaO2 by redistribution of pulmonary blood flow towards better ventilated parenchyma. One-third of patients are nonresponders to INO, however, and it is difficult to predict who will respond. The aim of the present study was to identify, within a panel of inflammato...

The specific antibody responses of mice to thymus-dependent polypeptide antigens are controlled by autosomal dominant immune response (Ir) genes which map in the I region of the H-2 complex (1). Primary responses in vivo or in vitro to the linear copolymers GAT ~ (L-glutamic acide°-L-alanine3°-L-tyrosine ~°) and GA (L-glutamic acidJ°-L-alanine 5°) are restricted to the IgG class in responder mi...

The possibility was investigated that Ir genes regulate the function of cells other than T or B cells in the primary IgM responses to the synthetic antigens trinitrophenylated poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys [TNP-(T,G)-A--L]and trinitrophenylated poly-,-(His,Glu)-poly-D, L-Ala--poly-L-Lys [TNP-(H,G)-A--L]. The primary responses of (B10 x B10.A)F(1) spleen cells to both antigens were a...