نتایج جستجو برای: nonmelanoma skin cancer

تعداد نتایج: 1082776  

Journal: :The New England journal of medicine 2016
Andrew C Chen Andrew J Martin Diona L Damian

Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelan...

2014
Nancy M. Nix Olivia Burdine Makeda Walker

© 2014 Harborside Press® Skin cancer is the most common cancer type in the United States, affecting more than 3 million people nationally (Cirrone & Harris, 2012). Basal cell carcinoma (BCC) and squamous cell carcinoma are the two main types of nonmelanoma skin cancer, while the more serious form, melanoma, is in its own category. An estimated 80% of nonmelanoma skin cancers are BCCs (Sekulic e...

Journal: :Cancer research 1995
S Kanjilal S S Strom G L Clayman R S Weber A K el-Naggar V Kapur K K Cummings L A Hill M R Spitz M L Kripke

Multiple and distinct p53 mutations were detected by DNA sequence analysis in tumor and adjacent nonmalignant skin samples from eight patients with nonmelanoma skin cancer of the head and neck, providing unambiguous evidence for field cancerization. The mutations consisted of C-->T transitions at dipyrimidine sequences (30% of all single base substitutions), T-->C transitions (47%), and G-->T t...

2010
Craig A. Elmets Jaye L. Viner Alice P. Pentland Wendy Cantrell Hui-Yi Lin Howard Bailey Sewon Kang Kenneth G. Linden Michael Heffernan Madeleine Duvic Ellen Richmond Boni E. Elewski Asad Umar Walter Bell Gary B. Gordon

BACKGROUND Preclinical studies indicate that the enzyme cyclooxygenase 2 plays an important role in ultraviolet-induced skin cancers. We evaluated the efficacy and safety of celecoxib, a cyclooxygenase 2 inhibitor, as a chemopreventive agent for actinic keratoses, the premalignant precursor of nonmelanoma skin cancers, and for nonmelanoma skin cancers, including cutaneous squamous cell carcinom...

Journal: :Archives of dermatology 2006
Basil M Hantash Daniel B Stewart Zachary A Cooper Wingfield E Rehmus R James Koch Susan M Swetter

OBJECTIVE To determine the effect of facial skin resurfacing for treatment of actinic keratoses (AKs) and prophylaxis against new primary basal and squamous cell carcinomas in individuals with previous nonmelanoma skin cancer (NMSC) or severe photodamage. DESIGN Randomized, prospective 5-year trial. SETTING Dermatology and otolaryngology clinics of a Veterans Affairs hospital. PATIENTS Th...

Journal: :Advances in experimental medicine and biology 2008
Melanie A Carless Lyn R Griffiths

Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, actinic keratosis, Merkel cell carcinoma and cutaneous lymphomas with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen's disease and derm...

Journal: :Plastic and Reconstructive Surgery - Global Open 2020

Journal: :Archives of dermatology 2005
Fergal J Moloney Esmaeel Almarzouqi Patrick O'Kelly Peter Conlon Gillian M Murphy

OBJECTIVE To determine the degree of compliance with sunscreen use among renal transplant recipients before and after transplantation and to determine risk factors associated with skin carcinogenesis. DESIGN Single-observer study with structured interview using a standardized questionnaire. Medical records and histology reports were examined for details of prior skin cancer. Cox proportional ...

Journal: :JNCI Journal of the National Cancer Institute 2008

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