Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex elimination of mAbs. This new model was firstly utilized to fit with the single-dose plasma concent...

We have developed an imaging method for locating isolated nonlinear scattering source~s! in solids. It relies on extracting the nonlinear response of a solid by modulation of a high by a low-frequency wave, and employing moving-window, synchronous detection. The resulting image consists of nonlinear wave reflection profiles with remarkable sensitivity to an isolated elastic nonlinear source~s!....

We present here a method for generating second-harmonic beams with tailored beam profiles using nonlinear metasurfaces based on split ring resonators. By manipulating both the phase and the amplitude of the quadratic nonlinear coefficient locally, at the single inclusion level, the emitted secondharmonic wavefront is perfectly controlled. These concepts are demonstrated experimentally by the fa...

With modern technologies such as microarray, deep sequencing, and liquid chromatography-mass spectrometry (LC-MS), it is possible to measure the expression levels of thousands of genes/proteins simultaneously to unravel important biological processes. A very first step towards elucidating hidden patterns and understanding the massive data is the application of clustering techniques. Nonlinear r...

Nonlinear simulation with a simple resistive magnetohydrodynamics model is used to investigate the stabilization of magnetic fluctuations in reversed-field pinch plasmas subject to pulsedparallel current drive (PPCD). Numerical results are diagnosed with computations of nonlinear power transfer and by evaluating sequences of profiles for linear stability. Results show that poloidal electric fie...

There are practical situations in which the quality of a process or product can be better characterized by a functional relationship between a response variable and one or more explanatory variables, which is called profile. Such profiles frequently can be represented adequately using linear or nonlinear models. While there are several studies in monitoring profiles, there are few studies to ev...

We study the localized modes created by introducing a resonant defect in a mechanical lattice. We find that modes introduced by resonant defects have profiles that can be tuned from being extremely localized to totally delocalized by an external force. This is in direct contrast with modes introduced by traditional mass or stiffness defects, in which the modes' profiles stay constant. We presen...

We conduct molecular dynamics simulations of athermal systems undergoing boundary-driven planar shear flow in two and three spatial dimensions. We find that these systems possess nonlinear mean velocity profiles when the velocity u of the shearing wall exceeds a critical value u(c). Above u(c), we also show that the packing fraction and mean-square velocity profiles become spatially dependent w...

A degenerate nonlinear nonlocal evolution equation is considered; it can be understood as a porous medium equation whose pressure law is nonlinear and nonlocal. We show the existence of sign changing weak solutions to the corresponding Cauchy problem. Moreover, we construct explicit compactly supported selfsimilar solutions which generalize Barenblatt profiles — the well-known solutions of the ...

We discover analytically an extensive family of optical similaritons, propagating inside graded-index nonlinear waveguide amplifiers. We show that there exists a one-to-one correspondence between these novel similaritons and standard solitons of the homogeneous nonlinear Schrödinger equation. We demonstrate that for certain inhomogeneity and gain profiles, the newly discovered similaritons turn...