نتایج جستجو برای: noncatalytic
تعداد نتایج: 704 فیلتر نتایج به سال:
Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a noncatalytic protein scaffold, we recently generated a new RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopted an entirely new structure with substantially enhanced conformational dynamics, demonstrating that ...
Heterogeneous chemical looping combustion (CLC) reactions and conjugate transports in large oxygen carrier particles were numerically investigated with computational fluid dynamics (CFD) approaches, which a simplified noncatalytic reaction model was implemented for reducing intraparticle modelling computation. Volumic gas-solid treated as surface based on the equivalent internal particle model....
Designing selective inhibitors of proteases has proven problematic, in part because pharmacophores that confer potency exploit the conserved catalytic apparatus. We developed a fundamentally different approach by designing irreversible inhibitors that target noncatalytic cysteines that are structurally unique to a target in a protein family. We have successfully applied this approach to the imp...
The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment encoding for the Bos taurus (cattle) albumin mRNA and subjected it to test-tu...
Article history: Received 5 May 2016 Accepted 5 May 2016 Available online 7 May 2016 lishment of latency, as the cellular transcriptional state influences both HIV transcription driven by its promoter located in the long terminal region (LTR) and reactivation from latency. Inhibitors that target the interaction between integrase and LEDGF are variously termed noncatalytic integrase inhibitors (...
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