Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we synthesized studied the properties of a novel nitrocatechol compound (1c) other analogs that structurally related to catechol derivative dynasore. Interestingly, 1c strongly inhibited two DEDD box HIV-1 RNase H SARS-CoV...

The degradation of p-nitrobenzoate (p-NBA) by domestic sewage was inhibited by benzoate, and a model for this behavior was found in a soil isolate. The isolate, a pseudomonad, utilized p-NBA and benzoate by separate adaptive enzyme pathways. In oxygen uptake experiments, the degradation of p-NBA was competitively inhibited by benzoate, but the degradation of benzoate was not affected by the pre...

The system vanadium(IV) – 4-nitrocatechol (NC) – iodonitrotetrazolium chloride (INT) water – chloroform is studied. The optimum conditions for complex formation and extraction into chloroform are found: pH=3.9-4.5 and reagent concentrations at least 2x10 mol l NC and 1.2x10 mol l INT. The composition of the ternary complex is found to be V(IV):NC:INT = 1:2:2 with maximum absorbance at 350 nm. B...

Abstract. Wildfires are increasing in size across the western US, leading to increases human smoke exposure and associated negative health impacts. The impact of biomass burning (BB) smoke, including wildfires, on regional air quality depends emissions, transport, chemistry, oxidation emitted BB volatile organic compounds (BBVOCs) by hydroxyl radical (OH), nitrate (NO3), ozone (O3). During dayt...

BACKGROUND Substituted catechols are important precursors for large-scale synthesis of pharmaceuticals and other industrial products. Most of the reported chemical synthesis methods are expensive and insufficient at industrial level. However, biological processes for production of substituted catechols could be highly selective and suitable for industrial purposes. RESULTS We have optimized a...

Biomass burning is a major source of light-absorbing organic aerosol (brown carbon), but its composition, chemical evolution, and lifetime are not well known. We measured water-soluble brown carbon absorption from 310 to 500 nm on the National Oceanic Atmospheric Administration Twin Otter aircraft during flights downwind western United States wildfires in summer 2019. The sampling strategy was ...

Catechol-O-methyltransferase (COMT) is an enzyme that plays an important role in the inactivation of catecholamine neurotransmitters. Experimental and clinical data suggest that COMT inhibitors may be useful in Parkinsonian patients. Among COMT inhibitors, nitrocatechol derivatives are the most potent and selective. In this study, we evaluated the kinetics of rat brain COMT, as well as its mech...

Arthrobacter protophormiae strain RKJ100 is capable of utilizing p-nitrophenol (PNP) as well as 4-nitrocatechol (NC) as the sole source of carbon, nitrogen and energy. The degradation of PNP and NC by this microorganism takes place through an oxidative route, as stoichiometry of nitrite molecules was observed when the strain was grown on PNP or NC as sole carbon and energy sources. The degradat...