نتایج جستجو برای: nitric oxide

تعداد نتایج: 179241  

Hassanpour H Heidari Nasirabadi M, Hematian Khayat S Khalili Sadr Abad E

Background: Chicken sertoli cells are a model to evaluate the effects of toxic Materialss. These cells can actively proliferate in the in vitro conditions and they are able to passage several times. Because of the widespread use of nanosilver in life and also few studies on the effects of these Materialss on different cell lines, evaluation of its toxic effects is felt. Mechanism of nanosilver ...

Introduction: Repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. Endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. The aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. Me...

Journal: :iranian journal of pharmaceutical research 0
ezgi gediz akdeniz university school of medicine department of pharmacology edibe minareci akdeniz university school of medicine department of pharmacology cahit nacitarhan akdeniz university school of medicine department of pharmacology gulay sadan akdeniz university school of medicine department of pharmacology

in this study, we aimed to investigate the peripheral antinociception effects of specificphosphodiesterase 5 (pde-5) inhibitor vardenafil on carrageenan-induced nociception in rats,and the role of calcium besides the l-arginine- nitric oxide (no)- cyclic guanosine monophophate(cgmp) pathway in these effects. hyperalgesia was induced by the intraplantar injection of 0.1ml fresh carrageenan solut...

Journal: :acta medica iranica 0
hamed shafaroodi department of pharmacology and toxicology, pharmaceutical sciences branch, islamic azad university, tehran, iran. mehrdad hashemi department of genetics, school of medicine, tehran medical branch, islamic azad university, tehran, iran. zahra nadia sharif department of anatomy, school of medicine, tehran medical branch, islamic azad university, tehran, iran. leila moezi department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran. and department of phytopharmaceuticals, pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran. zeinab janahmadi department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran. and the persian gulf marine biotechnology research center, bushehr university of medical sciences, bushehr, iran. ahmad reza dehpour department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

cirrhosis is associated with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. the aim of this study was to investigate the effect of cirrhosis on heart apoptosis and involvement of nitric oxide (no) and oxidative stress in the possible altered apoptosis of cirrhotic hearts. twenty-eight days after bile duct ligation, heart tissues wer...

Journal: :iranian biomedical journal 0
اصغر قاسمی asghar ghasemi صالح زاهدی اصل saleh zahediasl

nitric oxide (no) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. recent evidences suggest that no may act as an endocrine molecule. the aim of this review is considering available literature on endocrine roles of no and/or its metabolites, i.e. nitrite and nitrate. existing data suggest the idea that no is a hormone that after production i...

Journal: :iranian biomedical journal 0
محسن خلیلی mohsen khalili جمشید نارنجکار jamshid narengkar

it is a well-established fact that adenosine and its receptor subtypes (a 1 and a ) are involved in changes of contractility, heart rate and coronary blood flow (cbf) under different circumstances. this study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. for this purpose, nitro-l-arginine methyl ester (l-name), and indomethacin as inhibit...

Journal: :iranian journal of parasitology 0
somaye sadeghi negar seyed sima rafati tahereh taheri

background: the present study was conducted to investigate the optimized timing for macrophages induction and nitric oxide (no) production against invading leishmania parasite. methods: the present study examined the murine macrophage cell line, b10r, in three different states. in the first state, the cells were first infected with l. major and then treated with ifn-g and lps as stimulants. in ...

Journal: :anatomical sciences journal 0
fatemeh sabbaghziarani department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran keywan mortezaee department of anatomy, school of medicine, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) golamreza hassanzadeh department of anatomy, school of medicine, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) seyed mohammad hossein noori-mugahi department of anatomy, school of medicine, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

introduction: nitric oxide (no), as a free radical, involves in several physiologic functions in gi tract such as nerve impulse transmission and vascular tonicity regulation. nitric oxide synthase (nos) is the enzyme for the production of no from l-arginine which in turn inhibits by l-ngnitroarginine methyl ester (l-name). in the current work, we aimed to evaluate morphometric analysis of duode...

Journal: :Anesthesiology 2008
Yasuko Nagasaka Bernadette O Fernandez Maria F Garcia-Saura Bodil Petersen Fumito Ichinose Kenneth D Bloch Martin Feelisch Warren M Zapol

BACKGROUND Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood. METHODS The authors investigated the fate of inhaled nitric oxide (80 parts per million) in mice and quantified the formation of nitric oxide metabolites in blood and tissues....

Ghorbani, M, Maghsoudlu, Y, Moaeedi, A, Sadeghi Mahoonak, AR, Zakeri, K,

Background and Objectives: In this study, hydrolysis condition optimization of the pumpkin (Cucurbita pepo) seed proteins was carried out achieve maximum DPPH radical scavenging and nitric-oxide inhibition properties using Design Expert Software and response surface methodology.  Materials & Methods: In general, 1–3% concentrations of pepsin enzyme, 30–40 °C temperature and 120–100 min time we...

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