The objective of the present study was to prepare a stable iv injectable formulation of ascorbic acid and α-tocopherol in preventing the cerebral ischemia. Different niosomal formulations were prepared by Span and Tween mixed with cholesterol. The physicochemical characteristics of niosomal formulations were evaluated in vitro. For in vivo evaluation, the rats were made ischemic by middle cereb...

Niosomes have been reported as possible approach to improve the low corneal penetration and bioavailability characteristics for many drugs. The purpose of this study was to prepare and characterize an effective ocular niosomal hydrogel containing 0.5% (w/v) atenolol which is β1 adrenoceptor blocker for treatment of glaucoma. Thin film hydration method was used for the preparation of niosomes us...

This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed span 60 cholesterol. The results showed that addition chitosan increased particle sizes ζ-potentials. UA with layers had higher in HeLa than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, improved uptake, which clathrin-me...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation exa...

The emerging technology of drug-encapsulated nanoparticles plays a critical role in the development of treatment for various life-threatening diseases due to the versatility, control, and future potential of the design of these systems. A current treatment technique for the treatment of brain tumor cells, after major surgery, utilizes a drug adhered to a biodegradable polymer wafer that provide...

Over the years, researchers have attempted to improve potency of medicament utilization for treatment a variety diseases. Drug targeting is phenomenon in which drug distributed body such way that it interacts with target tissue at cellular or sub-cellular level achieve desired therapeutic response site while avoiding unwanted interactions other sites. This can be accomplished using modern deliv...

  Background :Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture.   Methods : In-vitro...

Loratadine is an efficacious, non-drowsy antihistaminic molecule prescribed for allergic skin. The conventional oral dosage form associated with various side effects, limited and variable absorption. present study attempts to improve the effectiveness of drug by formulating a niosome loaded hydrogel loratadine treating Ether injection method was used prepare niosomes using Box Behnken design. P...

Glaucoma is a common progressive eye disorder and the treatment strategies will benefit from nanoparticulate delivery systems with high drug loading and sustained delivery of intraocular pressure lowering agents. Niosomes have been reported as a novel approach to improve drug low corneal penetration and bioavailability characteristics. Along with this, poor entrapment efficiency of hydrophilic ...