Nonionic surfactant based vesicles (niosomes) are novel drug delivery systems formed from the self-assembly of nonionic amphiphiles in aqueous media. In the present study niosomal formulations of Paclitaxel (PCT), an antineoplastic agent, were prepared using different surfactants (Tween 20, 60, Span 20, 40, 60, Brij 76, 78, 72) by film hydration method. PCT was successfully entrapped in all of ...

Background/aim: Methotrexate (MTX) is a folic acid antagonist that widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune inflammatory diseases. The most important concerns with MTX are its poor solubility high toxicity, particularly in liver cells. To enhance minimize we encapsulated niosomes investigated hepatotoxicity mechanisms using genetic biomarkers. Materials methods...

Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index...

Abstract Background The problems associated with the poor water solubility of anticancer drugs are one most important challenges in achieving effective cancer therapy. present study was designed to evaluate effect scutellarein on human colon cells vitro by using a target α v β3 novel (Scu)-loaded niosome nanoparticle (β-CD-CL-Scu-cRGD). Results β-CD-CL-Scu-cRGD has diameter 140.2 nm and zeta po...