Ushbu maqolada sug‘urta shartnomasida qo‘llaniladigan franshiza moliyaviy instrumenti haqida so‘z yuritiladi. Shuningdek, nima ekanligi, uning shartnomasidagi o‘rni hamda turlari muhokama etiladi. Sug‘urta franshizasining shartnomasi ishtirokchilari uchun afzalliklari tahlil

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.

nimT encodes a protein in Aspergillus nidulans that is required for tyrosine dephosphorylation of p34cdc2 and has a strong homology to cdc25-type proteins. Conditional mutation of nimT (nimT23 mutation) arrests cells in G2 at the restrictive temperature. After release of the temperature-sensitive nimT23 block, p34cdc2 undergoes tyrosine dephosphorylation and we showed that as cells entered mito...

Cord blood (CB) hematopoietic stem cell transplantation can be successful even if donor and recipient are not fully matched for human leukocyte antigens (HLA). This may result from tolerance-inducing events during pregnancy but to date this concept has not been tested in CB transplantation. Hence we analyzed the impact of fetal exposure to noninherited maternal antigens (NIMA) of the HLA-A, -B ...

OBJECTIVES The aim of this study was to screen for infections caused by metronidazole (MTZ)-resistant Bacteroides spp., and to characterize the genes that encode the MTZ resistance. MATERIALS AND METHODS A total of 7 MTZ-resistant Bacteroides spp. were isolated from 5 patients with MTZ-resistant infections. These organisms were investigated for carriage of genes that encode MTZ resistance. Th...

A unique approach is developed for evaluating personnel requirements of the National Imagery and Mapping Agency (NIMA). With this approach new ways of measuring personnel availability are proposed and available to ensure that NIMA remains ready to provide timely, relevant, and accurate imagery, imagery intelligence and geospatial information in support of the national security objectives of the...

Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA-region contributes most to the genetic risk. HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e., HLA-DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304) are associated with protection from RA. It has been proposed that not only inherited but also noninherited HLA-antigens from the mother (NIMA) can infl...

At the time of its publication, Nima Yushij’s “Qoqnus” (The Phoenix) emerged as a radical departure from the norms and conventions of classical Persian poetry. Nima employed phoenix symbolism in this poem to present his zeal for a literary renaissance. Likewise, George Darley (1795-1846), the Irish Romantic poet who found himself lonely and isolated at the mitigating time borders of Romanticism...

Based on the hypothesis that long-term fetomaternal microchimerism is associated with acquired immunologic hyporesponsiveness to noninherited maternal antigens (NIMAs) or inherited paternal antigens (IPAs), several groups have recently reported successful cases of non-T-cell-depleted hematopoietic stem cell transplantation (SCT) from HLA-haploidentical family members mismatched for NIMAs. In th...