In this paper, we report the development of micromachining techniques for a biodegradable polymer for the first time. By virtue of their ability to naturally degrade in tissues, biodegradable polymers hold immense promise as new materials for implantable biomedical microdevices. This work focuses on the establishment of microfabrication processes for biodegradable microstructures and microdevic...

Polycaprolactone/Hydroxyapatite (PCL/HA) composite is an excellent material for fabricating tissue engineering scaffolds, especially as bone scaffolds. However, polarity differences between the hydrophilic HA and the hydrophobic PCL often leads to poor dispersion during the blending process. This is due to the tendency of the HA particles to agglomerate, and the difficulty to efficiently mix th...

A promising therapy for retinal diseases is to employ biodegradable scaffolds to deliver retinal progenitor cells (RPCs) for repairing damaged or diseased retinal tissue. In the present study, cationic chitosan-graft-poly(ɛ-caprolactone)/polycaprolactone (CS-PCL/PCL) hybrid scaffolds were successfully prepared by electrospinning. Characterization of the obtained nanofibrous scaffolds indicated ...

This is a comprehensive study reporting the fabrication of highly porous Gehlenite scaffold (Ca2Al2SiO7)—both with and without surface modification—for first time. The sintering temperature scaffolds was optimized. Next, optimized coated by polycaprolactone (PCL)-Forsterite (Mg2SiO4) nanocomposite to improve scaffold’s brittleness biological properties. 1375 °C found be which consolidated. Diff...

The main aim of this study was to test the biopolymer polycaprolactone (PCL) as an electrode modifier for electrochemical detection dopamine (DA). PCL chosen following a search polymers with appropriate geometry and functional groups detection. chemical structure average molecular weight synthesized were determined by 1H NMR, while DSC measurements showed decrease in crystallinity star-shaped p...

Freeform fabrication provides an effective process tool to manufacture advanced tissue scaffolds with specific designed properties. Our research focuses on using a novel Precision Extrusion Deposition (PED) process technique to directly fabricate Polycaprolactone (PCL) and composite PCL/ Hydroxyapatite (HA) tissue scaffolds. The scaffold morphology and the mechanical properties were evaluated u...

Biodegradabilities of polymers and their composites in a controlled compost were described. Polycaprolactone (PCL) and poly(lactic acid) (PLA) were employed as biodegradable polymers. Biodegradabilities of PCL and PLA samples in a controlled compost were measured using a Microbial Oxidative Degradation Analyzer (MODA) according to ISO 14855-2. Sample preparation method for biodegradation test a...

PURPOSE The aim of this prospective study was to evaluate whether blending two kinds of biomaterials, chitosan and polycaprolactone (PCL), can be used as scaffold and carrier for growth and differentiation of corneal endothelial cells (CECs). METHODS A transparent, biocompatible carrier with cultured CECs on scaffold would be a perfect replacement graft. In the initial part of experiment, for...

Physical properties of scaffolds intended for myocardial tissue regeneration were studied. Mechanical properties and degradation rates were evaluated for degradable scaffolds composed of poly (2-hydroxyethyl methacrylate) (pHEMA) crosslinked with polycaprolactone (PCL). pHEMA copolymerized with tetraethylene glycol as a crosslinker served as a control. Fibroblast cells were used for cytotoxicit...

Polycaprolactone (PCL) is biodegradable and non-toxic, making it an eco-friendly polymer with various medical applications. In order to increase the stability of PCL used in field applications, necessary be able produce fibers a melt electrospinning method that does not use toxic hydrophobic solvents. However, has very high viscosity low conductivity, difficult. This study presents natural addi...