Cadmium (Cd), a widespread cumulative pollutant, is a known human carcinogen, associated with inflammation and tumors. Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in tumor metastasis; however, the mechanisms underlying the MMP-9 expression induced by Cd remain obscure in human endothelial cells. Here, Cd elevated MMP-9 expression in dose- and time-dependent manners in human endothel...

BACKGROUND Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-tanapartholide (β-tan) isolated from Achillea falcata and salograviolide A (Sal A) isolat...

Rationale and objectivesFuzi, the dried root of Aconitum carmichaelii Debx, is one widely used traditional Chinese medicines. Fuzi polysaccharides are considered most bioactive compounds with immunomodulatory functions, however, mechanisms have not been evaluated. This study aims to systematically investigate effects on gut microbiota immune function using a mouse model immunosuppressed cycloph...

Adipocyte tissue inflammation orchestrates the occurrence and development of diseases induced by obesity. Here, effects Lagerstroemia speciosa (L.) Pers total flavonoids (LTF) on TNF-α-induced insulin resistance (IR) inflammatory response in 3T3-L1 adipocytes underlying mechanisms were studied. Cell glucose uptake test confirmed that TNF-α could induce IR adipocytes. The sensitivity to was incr...