BACKGROUND Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS We fitted a locally weighted polynomial regression line to daily mortality to estimate the number of deaths expected during th...

The article substantiates the importance of including sports holidays in work a coach within organizing judo classes with preschool children. reveals role festival as an effective means pedagogical influence. purpose study was to develop and test program for children section. 42 young judoists at age 5-6 years first year took part study. It is revealed that spos holidays, through creation emoti...

A dip and peak pattern of suicide around major public holidays has been found in developed countries and explained by the broken promise effect. Focusing on two major holidays in South Korea (New Year's Day and Thanksgiving Day, both on the lunar calendar), replication of the dip and peak pattern was done by analyzing individual information on all suicides from 1997 to 2014. The replicated patt...

Introduction: Tamoxifen is one of the most common treatment opportunities for hormonal positive breast cancer. Despite its good tolerability, patients demonstrate decreasing adherence over years impacting on therapeutic success. PBPK modeling was applied to demonstrate the impact of drug holidays on plasma levels of tamoxifen and its active metabolite endoxifen for different CYP2D6 genotypes. M...

OBJECTIVE To compare the mortality of patients in a palliative care unit on working days with that on weekends and public holidays. DESIGN Retrospective database study. SETTING Palliative care unit in Germany. POPULATION All admissions to palliative care unit between 1 January 1997 and 31 December 2008. MAIN OUTCOME MEASURE The impact of day type (working days or weekends and public hol...

If you are reading this editorial in the week of publication, chances are that you do not work in one of the countries bordering the Mediterranean. If you are in Scandinavia, this is probably your first opportunity even to read my editorial from July. Most of Europe now takes a full four or five weeks of vacation, usually corresponding to the calendar month of July in the north or August in the...

OBJECTIVE How do the holidays--and the possible New Year's resolutions that follow--influence a household's purchase patterns of healthier foods versus less healthy foods? This has important implications for both holiday food shopping and post-holiday shopping. METHODS 207 households were recruited to participate in a randomized-controlled trial conducted at two regional-grocery chain locatio...

Farm holidays are becoming more and more frequent in the choices of people. First of all, this is due to the less costs related to such kind of accommodation. But, apart this mere reason, it’s evident that farm holidays, thanks to the possibility of assessing closer relationships with people living in the surrounding areas, induce a sort of relational tourism, in this way facilitating the cultu...

Background Data regarding the influence of weekends and Chinese national holiday's admission on the outcomes of patients with ST-elevated myocardial infarction (STEMI) is lacking. This study sought to investigate the effect of Chinese national holidays and weekend admission on outcomes in patients with STEMI undergoing primary percutaneous coronary intervention (PPCI). Methods Patients presen...