The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in human helminth infection. Here, we demonstrate NETs formation in human onchocerciasis. Extracellular NETs and neutrophils were visualised arou...

Abstract Excessive epidural fibrosis attached to the dura mater is major cause of recurrent failed back surgery syndrome after spine surgery. Neutrophil extracellular traps (NETs) promote fibrosis, raising possibility that DNA backbone NETs may be a potential target in therapy fibrosis. Human body temperature-sensitive hydroxypropyl chitin hydrogel solutions were prepared encapsulate DNase I, w...

Ankylosing spondylitis (AS) is an inflammatory disease characterized by excessive bone formation. We investigated the presence of neutrophil extracellular traps (NETs) in AS and how they are involved osteogenic capacity marrow mesenchymal stem cells (MSCs) through interleukin-17A (IL-17A). Peripheral neutrophils sera were obtained from patients with active healthy controls. NET formation neutro...

Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an EL...

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung by regulating recruitment neutrophils and formation neutrophil extracellular traps (NETs). CTSC enzymatically activates membrane-boun...

Background: Neutrophil extracellular traps (NETs) are chromatin complexes of cell-free DNA and histones, with attached neutrophil granular proteins which trap kill infectious microbes. NETs essential in host defense, also linked to inflammation autoimmunity, including systemic lupus erythematosus (SLE) recently emerged as contributor arterial venous thrombosis. Common carotid intema media thick...

Constitutively active neutrophil extracellular traps (NETs) and elevated plasma homocysteine are independent risk factors for Type 2 Diabetes (T2D) associated vascular diseases. Here, we show robust NETosis due to elevated plasma homocysteine levels in T2D subjects and increased components of NETs such as neutrophil elastase and cell free DNA. Cooperative NETs formation was observed in neutroph...

Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida growth and dissemination. Considering the resilience of Candida biofilms to host defenses, we examined the neutrophil response to C. albicans during biofilm growth. In contrast to planktonic C. albicans, biofilms triggered negligible relea...

Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred to as neutrophil extracellular traps (NETs). NETs are composed of DNA strands associated with histones and decorated with about 20 different pr...