نتایج جستجو برای: neutral comet assay
تعداد نتایج: 307083 فیلتر نتایج به سال:
background: cadmium (cd) is a heavy metal which is widely spread in our surroundings and has a very strong ability to accumulate in the body organs such as spleen. in this study we aimed to determine the genotoxicity and cytotoxicity effects on mice spleen treated with cadmium. methods: thirty male mice were enrolled in this study and kept in standard conditions. mice were randomly divided int...
background: agriculture is an important sector for the malaysian economy. the use of pesticides in agriculture is crucial due to its function in keeping the crops from harmful insects. children living near agricultural fields are at risk of pesticide poisoning. objective: to evaluate the genotoxic risk among children who exposed to pesticides and measure dna damage due to pesticides exposure. m...
The comet assay has been widely used to measure a range of cellular responses to DNA damage and has found applications in genotoxicity studies, bio-monitoring, ecological testing and in the study of human disease. This review discusses how the comet assay has been applied to the study of DNA damage and repair associated with cancer. The potential of the assay as a tool for predicting an individ...
The in vivo alkaline single cell gel electrophoresis assay, hereafter the Comet assay, can be used to investigate the genotoxicity of industrial chemicals, biocides, agrochemicals and pharmaceuticals. The major advantages of this assay include the relative ease of application to any tissue of interest, the detection of multiple classes of DNA damage and the generation of data at the level of th...
The vertical comet assay is a relatively new technique for quantitatively measuring radiation induced DNA damage in cells. The vertical comet assay provides potential for measuring DNA strand breaks in a dense monolayer of plated cells. This paper explores the successes and challenges of developing a vertical comet assay system for use with the current Microbeam II alpha particle source at RARA...
butachlor (n-(butoxymethyl)-2-chloro-n-2, 6-diethylacetanillide) is widely used chloroacetanilide herbicide in asian region, especially in the north of iran. several studies have been reported on toxicity of butachlor, but little information is accessible on dna damaging potential. thus, the present study was undertaken to investigate of dna damage by butachlor in cyprinuscarpio(pisces: cyprini...
malathion (s-(1, 2-dicarboethoxyethyl) o, o-dimethyl phosphorodithioate) is one of the organophosphate pesticides comprehensively used in agriculture fields throughout the world. in spite of widely used, little information are available about dna damage in aquatic organisms. therefore, the present study carried out to investigation of dna damage induced by malathion in cyprinus carpio (pisces: ...
objective: achillea is a traditional medicinal herb which contains different phenol and flavonoid compounds that are responsible for achillea pharmacological effects. we aimed to determine phenol and flavonoid contents, besides antioxidant activities of different extracts from achillea eriophoraa (a. eriophora) dc. and achillea biebersteinii (a. biebersteinii) afan. (endemic species in iran) an...
background: cadmium is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in kidney. the present study was done to determine the genotoxicity and cytotoxicity in kidneys of rats exposed to cadmium. methods: male rats (n=30), kept in standard conditions were used in this study. the animals were randomly divided into 2 group...
introduction: silymarin is obtained from silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its a...
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