OBJECTIVES To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association results based on 1000 Genomes imputation; to evaluate whether common genetic variants as assessed by single-nucleotide polymorphisms (SNPs) explain variation in neuroticism by estimating SNP-based heritability; and to examine whether SNPs that predict neuroticism also pre...

Epilepsy is one of the most common neurological disorders with a prevalence in the general population is three percent. The present study was correlational type. Statistical population of present study was all epilepsy patients of Esfahan city that 120 Temporal Lobe Epilepsy patients were selected as sample study in Alzahra hospital and epilepsy department of Masih. For data collection we used ...

BACKGROUND The relationship between neuroticism, depression and cardiovascular disease (CVD) is complex and has so far not been studied in depth. The aim of this study was to determine if neuroticism is an effect-modifier in the association between depression and CVD. Data derived from a longitudinal cohort study on mental health, work and relations among adults (20-64 years), including 10,443 ...

Existent research documents an unclear and contradictory pattern between cortisol and personality variables, especially neuroticism. Specifically, no effect, positive correlations and negative correlations have all been reported to exist between cortisol and neuroticism. The current study tested whether males and females have a fundamentally different relationship between HPA activation and neu...

OBJECTIVE The association between personality traits and mortality might differ as a function of socioeconomic status (SES). Our aim was to evaluate the all-cause, cardiovascular disease (CVD), and cancer mortality risk associated with neuroticism or extraversion and their interactions with SES in a representative sample of the UK adult population. METHODS A total of 5450 participants (2505 m...

Why is Neuroticism so harmful to marriage and other intimate relationships? Given that such relationships generally involve a sexual component, the current longitudinal study explored whether the apparent negative impact of own and partner's Neuroticism on marriage could be explained by dissatisfaction with the sexual relationship. Just after their weddings, 72 couples reported their marital sa...

Neuroticism predisposes to anxiety disorders, but the precise pathogenic mechanism is unknown. The aim of this study was to examine whether people with high neuroticism scores use a lower criterion for detecting danger in the face of ambiguous stimuli, and avoid a greater number of ambiguous stimuli than people with low neuroticism scores. Participants high and low in neuroticism were administe...

Neuroticism is a dimension of personality that captures trait individual differences in the tendency to experience negative thoughts and feelings. Established theories explain neuroticism in terms of threat sensitivity, but have limited heuristic value since they cannot account for features of neuroticism that are unrelated to threat, such as creativity and negative psychological states experie...

Neuroticism, a broad personality trait linked to negative emotions, is consistently linked to ill health when self-report is used to assess health. However, when health risk is assessed with biomarkers, the evidence is inconsistent. Here, we tested the hypothesis that the association between neuroticism and biological health risk is moderated by behavioral adjustment, a propensity to flexibly a...

The present study aimed to reveal the role of neuroticism on the relationship between self-esteem and aggressive emotion. We conducted a cross-sectional study in which a battery of self-report questionnaires was used to assess self-esteem, neuroticism and aggressive emotion in 1085 Chinese adolescents (N = 1085, Mage = 16.38 years, 753 boys). We found that self-esteem could make a negative pred...