Neuromuscular Junction (NMJ) is the place where the neuron meets with muscle fiber crating a synapse to propagate the electrochemical signals. The infolds of the endplate of muscle fiber play a vital role containing a huge number of sodium channels in contraction of NMJ transmission mechanism. We have studied here the entanglement of sodium channel activation particle (‘m’ particle). Through th...

In this issue of Neuron, two studies by Pielage et al. and Bednarek and Caroni suggest that the cytoskeleton regulator β-Adducin provides an activity-dependent switch controlling synapse disassembly and assembly at the Drosophila neuromuscular junction (NMJ) and the mouse hippocampus. In mice, the β-Adducin switch is required for the improvement of learning and memory induced by enriched enviro...

The Muscular Dystrophy Campaign convened a workshop on 2nd February 2005 to draw up evidencebased recommendations for the management of respiratory problems in adults with muscle diseases. The strength of these recommendations was graded using the Scottish Intercollegiate Guidelines Network (SIGN) methodology (Table 1). Neurogenic conditions, neuromuscular junction disorders and myotonic dystro...

BACKGROUND AND OBJECTIVES The action mechanism of local anesthetics (LA) on neuromuscular junction motivated several studies. When administered at low doses, they do not interfere on neuromuscular transmission. But high doses may compromise neuromuscular transmission and increase the effects of neuromuscular blockers. The objective of this study was to evaluate lidocaine interaction with rocuro...