Following empirical studies on schizophrenic and bipolar vulnerabilities, research on endophenotypes knows a recent major development. Two main definitions of early and stable vulnerability markers may be distinguished. First, a strict definition of endophenotype relies on a quantifiable and mainly paraclinical measure (e.g., biological data, electrophysiology or functional imaging). Second, a ...

"PANESS" battery was administered to a total sample of 120 students of five age specific groups of children from two schools catering to the needs of different socio-economic classes. Most commonly observed item was overflow/higher movements (5, N = 24) followed by motor inco-ordination and dysdiadochokinesia, maximally present in the age group of 7 to 8 (6, N = 24). Further results suggest dif...

OBJECTIVE The primary objective of this study was to examine neurological soft signs in patients with obsessive-compulsive disorder compared with patients with schizophrenia and a control group in the Indian setting. The secondary objective was to find any correlation between age at onset and neurological soft signs scores, as well as that between severity of obsessive-compulsive disorder sympt...

OBJECTIVE Neurological soft signs are frequently found in schizophrenia. They are indicators of both genetic liability and psychopathological symptoms. To further differentiate "trait" and "state" relations the authors compared the 1-year course of neurological soft signs in schizophrenia patients and comparison subjects. METHOD Thirty-nine patients with first-episode schizophrenia spectrum d...

AIM To study the correlations between neurological signs and developmental performance, and to analyze the value of neurological signs in identification of developmental disabilities. METHODS A group of 26 preterm infants (gestational age from 23 weeks to 36 weeks) was studied. The neurological assessment described by Amiel-Tison and Gosselin was performed at term age and repeated every 3 mon...

BACKGROUND This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia. METHODS A cross-sectional design was adopted with the use of the Cambridge Neurological Inventory (CNI). The CNI is comprised of 7 subscales, including motor coordination, sensory integration, disinhibition, extrapyramidal signs, dyskinesia, catatonia, and pyramidal...

BACKGROUND Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. ...