نتایج جستجو برای: neuregulin1

تعداد نتایج: 82  

Journal: :Progress in neuro-psychopharmacology & biological psychiatry 2011
Amy E Geddes Xu-Feng Huang Kelly A Newell

Schizophrenia is a debilitating neurodevelopmental psychiatric disorder. Both the N-methyl-D-aspartate receptor (NMDAR) and neuregulin1 (NRG1) are key molecules involved in normal brain development that have been linked to schizophrenia pathology and aetiology. The NR2 proteins are critical structural and functional subunits of the NMDAR and are developmentally and spatially regulated. Altered ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Young Il Lee Yue Li Michelle Mikesh Ian Smith Klaus-Armin Nave Markus H Schwab Wesley J Thompson

Synaptic connections in the nervous system are rearranged during development and in adulthood as a feature of growth, plasticity, aging, and disease. Glia are implicated as active participants in these changes. Here we investigated a signal that controls the participation of peripheral glia, the terminal Schwann cells (SCs), at the neuromuscular junction (NMJ) in mice. Transgenic manipulation o...

2012
Kavya Reddy Haesun A. Kim

Neuregulin1-ErbB signaling is important for various functions during Schwann cell development and myelination. Activation of the ErbB receptors also triggers myelin breakdown in mature myelinating Schwann cells. The mechanism by which the activated ErbB receptor complex elicits multiple biological functions in Schwann cells is unclear. In Charcot-Marie-Tooth (CMT) disease-the most common demyel...

2016
Takahiko Murayama Takashi Nakaoku Masato Enari Tatsunori Nishimura Kana Tominaga Asuka Nakata Arinobu Tojo Sumio Sugano Takashi Kohno Noriko Gotoh

The CD74-Neuregulin1 (NRG1) fusion gene was recently identified as novel driver of invasive mucinous adenocarcinoma, a malignant form of lung cancer. However, the function of the CD74-NRG1 fusion gene in adenocarcinoma pathogenesis and the mechanisms by which it may impart protumorigenic characteristics to cancer stem cells (CSC) is still unclear. In this study, we found that the expression of ...

Journal: :Reproductive biology and endocrinology : RB&E 2008
Keisuke Abé Ko Eto Shin-ichi Abé

The complex processes of spermatogenesis are regulated by various factors. The aim of the current study is to determine the effect of epidermal growth factor (EGF) on spermatogonial proliferation and clarify the mechanism causing the proliferation in newt testis. In the organ culture, EGF stimulated spermatogonial proliferation, but not their differentiation into spermatocytes. cDNA cloning ide...

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