Neural induction constitutes the first step in the generation of the vertebrate nervous system from embryonic ectoderm. Work with Xenopus ectodermal explants has suggested that epidermis is induced by BMP signals, whereas neural fates arise by default following BMP inhibition. In amniotes and ascidians, however, BMP inhibition does not appear to be sufficient for neural fate acquisition, which ...

Spemann’s organizer experiment in 1924 suggested that neural tissue is induced from prospective epidermal tissue by a secreted factor1. Since then, neural induction has been a focus of biological interest; however attempts to isolate a neural inducing factor remained unsuccessful for decades. Therefore, it came as a major relief when the molecular basis of neural induction in amphibia was unrav...

Suppression of bone morphogenetic protein (BMP) signaling induces neural induction in the ectoderm of developing embryos. BMP signaling inhibits eural induction via the expression of various neural suppressors. Previous research has demonstrated that the ectopic expression of dominant negative BMP receptors (DNBR) reduces the expression of target genes down-stream of BMP and leads to neural ind...

Vertebrate neural induction requires inhibition of bone morphogenetic protein (BMP) signaling in the ectoderm. However, whether inhibition of BMP signaling is sufficient to induce neural tissues in vivo remains controversial. Here we have addressed why inhibition of BMP/Smad1 signaling does not induce neural markers efficiently in Xenopus ventral ectoderm, and show that suppression of both Smad...

Objective(s): Nowadays much effort is being invested in order to diagnose the mechanisms involved in neural differentiation. By clarifying this, making desired neural cells in vitro and applying them into diverse neurological disorders suffered from neural cell malfunctions could be a feasible choice. Thus, the present study assessed the capability of fetal brain extract (FBE) to induce rat bon...

This article presents a sliding mode control (SMC) with artificial neural network (ANN) regulator for the doubly fed induction generator (DFIG) using two-level neural pulse width modulation (NPWM) technique. The proposed control scheme of the DFIG-based wind turbine system (WTS) combines the advantages of SMC control and ANN regulator. The reaching conditions, robustness and stability of the sy...