Human immunodeficiency virus type 1 Rev export depends upon the presence of the nuclear export signal (NES), a leucine-rich stretch of hydrophobic amino acids. Recently, the nuclear NES-binding receptor has been identified as CRM1 or exportin 1. Rev export has been shown to be CRM1 dependent. The function of the atypical NES-containing Rev-like proteins of equine infectious anemia virus (EIAV) ...

OBJECTIVE To compare the eating and sleep-wake patterns of persons with the night eating syndrome (NES) with those of matched control subjects. RESEARCH METHODS AND PROCEDURES Forty-six overweight/obese NES subjects (mean age 43.3 +/- 9.8 years; 32 women) and 43 similar controls (mean age 39.0 +/- 11.0 years; 28 women) wore wrist actigraphs for 7 days and completed sleep and food diaries at h...

Nonlinear Energy Sinks (NES) are used to passively reduce the amplitude of vibrations. This reduction is made possible by introducing a nonlinearly stiffening behavior in the NES, which might lead to an irreversible transfer of energy between the main system (e.g., a building) and the NES. However, this irreversible transfer, and therefore the efficiency of the NES, is strongly dependent on the...

Infections with parasitic helminths such as Nippostronglyus brasiliensis induce dominant type 2 responses from antigen-specific T helper cells. The potency of the Th2 bias can also drive Th2 responses to bystander antigens introduced at the same time as infection. We now report that the Th2-promoting effect of infection can be reproduced with soluble N. brasiliensis excretory-secretory proteins...

In this study, we address the response regimes of a novel Nonlinear Energy Sink (NES) that couples both cubic and impact nonlinearities. non-smooth condition, conventional multiple scales method is considered with condition. By identifying occurrence collision, asymptotic analysis equivalent NES model Vibro-Impact (VI) can illustrate fixed point Cubic (VIC) NES. Three types VIC are described as...

This laboratory investigation has been conducted to elucidate how the fi nes fraction affects the undrained residual shear strength and liquefaction potential of sand-silt mixtures (Algeria). A series of monotonic and cyclic undrained triaxial tests were carried out on undrained, reconstituted, saturated samples of sand with varying fi nes content ranging from 0 to 50%. These were undertaken in...

The karyopherin CRM1 mediates nuclear export of proteins and ribonucleoproteins bearing a leucine-rich nuclear export signal (NES). To elucidate the precise mechanism by which NES-cargos are dissociated from CRM1 in the cytoplasm, which is important for transport directionality, we determined a 2.0-A resolution crystal structure of yeast CRM1:RanBP1:RanGTP complex, an intermediate in the disass...

Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alterations functionally cooperate to delocalize NPM to the cytoplasm. Using a Rev(1.4)-...

The classical nuclear export signal (NES), also known as the leucine-rich NES, is a protein localization signal often involved in important processes such as signal transduction and cell cycle regulation. Although 15 years has passed since its discovery, limited structural information and high sequence diversity have hampered understanding of the NES. Several consensus sequences have been propo...

The Nash equilibria set (NES) is described as an intersection of graphs of best response mappings. The problem of NES computing for multi-matrix extended games is considered. A method for NES computing is studied. Mathematics Subject Classification 2000: 91A05, 91A06, 91A10, 91A44, 90C05, 90C31, 90C90.