Misdirection of regenerating axons is one of the factors that can explain the poor results often found after nerve injury and repair. In this study, we quantified the degree of misdirection and the effect on recovery of function after different types of nerve injury and repair in the rat sciatic nerve model; crush injury, direct coaptation, and autograft repair. Sequential tracing with retrogra...

A nerve gap is defined as the distance between two ends of a divided nerve. It is caused not just by the nerve tissue lost due to the trauma, or to the following debridement, but also by the actual retraction of the nerve stumps. The retraction is due to the elastic properties of the nerve fibers. Only small nerve gaps, in which minimal tension is required to contrast the elastic properties of ...

Microsurgical suturing is the gold standard of nerve coaptation. Although literature on the usefulness of fibrin glue as an alternative is becoming increasingly available, it remains contradictory. Furthermore, no data exist on how both repair methods might influence the morphological aspects (arborization; branching) of early peripheral nerve regeneration. We used the sciatic nerve transplanta...

The repair of injured or transected nerves is frequently encountered in head and neck surgery. Recently, CO2 lasers with milliwatt capability and micrometer spot sizes have been developed that may be used in nerve anastomosis. A comparative study was performed between microsuture and CO2 laser repair of transected sciatic nerves in rats. Nerve regeneration was measured in terms of morphology, e...

Autograft is gold standard treatment for peripheral nerve repair up to now. Eggshell membrane (ESM) as nerve guide channel effectively enhances nerve regeneration. Dimethyl sulphoxide (DMSO) has anti-inflammatory and anti-oxidant properties. The aim of this study was to evaluate the effect of DMSO+eggshell membrane guide channel on sciatic nerve regeneration in rats. Thirty two adult male rats ...

In this study, we constructed tissue-engineered nerves with acellular nerve allografts in Sprague-Dawley rats, which were prepared using chemical detergents-enzymatic digestion and mechanical methods, in combination with bone marrow mesenchymal stem cells of Wistar rats cultured in vitro, to repair 15 mm sciatic bone defects in Wistar rats. At postoperative 12 weeks, electrophysiological detect...

INTRODUCTION Facial nerve injury leads to significant disability and impairment in quality of life. Nerve repair is the best treatment for facial nerve injury. Suture neurorrhaphy under microscopic magnification has been considered the gold standard for repair, but this method can be technically challenging and time consuming. Furthermore, sutures are traumatic, leading to scar formation that c...

BACKGROUND Electrical stimulation (ES) has been proven to be an effective means of enhancing the speed and accuracy of nerve regeneration. However, these results were recorded when the procedure was performed almost immediately after nerve injury. In clinical settings, most patients cannot be treated immediately. Some patients with serious trauma or contaminated wounds need to wait for nerve re...

OBJECTIVE Options for nerve repair are limited in brachial plexus lesions with multiple root avulsions because an insufficient number of proximal nerve stumps are available to serve as lead-out for nerve grafts. End-to-side nerve repair might be an alternative surgical technique for repair of such severe lesions. In this technique, an epineurial window is created in a healthy nerve, and the dis...