Detection and primary processing of physical, chemical and thermal sensory stimuli by peripheral sensory nerve fibers is key to sensory perception in animals and humans. These peripheral sensory nerve fibers express a plethora of receptors and ion channel proteins which detect and initiate specific sensory stimuli. Methods are available to characterize the electrical properties of peripheral se...

STUDY DESIGN Immunohistochemical study of the sensory innervation of the human lumbar intervertebral disc. OBJECTIVE To determine the type of sensory fibers innervating human degenerated lumbar intervertebral discs. SUMMARY OF BACKGROUND DATA Sensory neurons involved in pain perception related to inflammation in rats are typically small, peptide-containing neurons immunoreactive for calcito...

The nerve fiber distribution in the oral mucosa of the soft palate and palatoglossal arch of the rat was studied by means of methylene blue supravital staining. It was focused primarily on the dye uptake of intraepithelial nerve fibers. Differences in the morphology of nerve fiber terminations were found between these regions of the oral mucosa. In the soft palate, local accumulations of intrae...

course of elongation and maturation of peripheral nerve fibers in the cat after crush of the tibial nerve in the proximal calf. Regeneration after crush alone was compared with crush 5 mm proximal to a tight constriction of the nerve. Regeneration was monitored by the progression of excitability along the electrode arrays on the tibial and plantar nerves. The sensitivity was sufficient to recor...

A B S T R A C T There are three types of nerve fibers that are involved in the transmission of pain stimuli: C fibers (slower fibers) for thermal, mechanical and chemical stimuli, A-delta fibers for thermal or mechanical stimuli and A-beta fibers for touch stimuli. Clinically, this is crucial in making an accurate assessment of the pain level experienced by a suffering patient, in indicating th...

The neural pathways followed by sensory fibers from arterial baroreceptors in the aortic region of the dog were investigated with neurophysiological recording. Systemic arterial baroreceptor fibers separate from the depressor nerve were found in the left cervical vagus in each of five dogs investigated; at most two fibers were isolated from each dog due to the difficulty of the dissection. Thes...

Muscle fiber-type grouping (‘clumping’) in cross-sections of patient muscle biopsies and the electrophysiological recordings of enlarged motor unit action potentials (MUAPs) are almost universally interpreted as peripheral nerve damage with subsequent reinnervation of denervated muscle fibers [1, 2]. Other electromyographic potentials, including nascent potentials, are indicators of early muscl...

Cross sections of olfactory nerves present a unique appearance. They indicate the presence of large numbers of very small nerve fibers, with a modal diameter of about 0.2 micro and a narrow range for their size variation. From one side of the nasal septum of a pig the yield of fibers was estimated at 6,000,000; the number arising from the turbinates would be considerably larger. The fibers are ...

Peripheral nerve injury repair is one of the most challenging problems in neurosurgery, partially due to lack of knowledge of three-dimensional (3-D) fine structure and organization of peripheral nerves. In this paper, we explored the structures of nerve fibers in ventral and dorsal nerves with a laser scanning confocal microscopy. Thick tissue staining results suggested that nerve fibers have ...

The optic nerves, tracts, and tecta of goldfish, 1 to 5 years old, have been studied anatomically using light and electron microscopy, horseradish peroxidase (HRP), and tritiated proline radioautography. The aims were to document an earlier inference that fibers are added to the nerve continually and to describe the growth and organization of the pathway. (1) The numbers of optic fibers were co...