.....................................3 Introduction...............................4 Materials and Methods...........17 Results........................................21 Development of the Ex vivo Assay.............................................................................................................21 Wallerian Degeneration Proceeds Normally in the Ex vivo Assay..........................

In a substrain of C57BL mice, C57BL/Ola, Wallerian degeneration in the distal segment of the severed sciatic nerve is extremely slow when compared to other mice. Despite this very slow degeneration in the distal segment regeneration of the motor nerves is not impaired. From suitable genetic outcrosses and backcrosses, the authors provide evidence that the rate of Wallerian degeneration in this ...

A 48-year-old man with hypertension, hyperlipidemia, and hypothyroidism presented to an outside institution progressive bilateral lower extremity numbness weakness. Nerve conduction studies (NCS) suggested acquired demyelinating polyneuropathy. Right sural nerve biopsy revealed mild chronic neuropathy, axonal degeneration, demyelination, remyelination. He received monthly IV immunoglobulin (IVI...

ABSTRACT Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from nucleus to cytoplasm is a common feature neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects this mislocalization are not well understood. To investigate impact mislocalized TDP-43 on neuronal cell ...

Previous reports showed that short-term hyperglycemia protects optic nerve axons in a rat experimental hypertensive glaucoma model. In this study, we investigated whether short-term hyperglycemia prevents tumor necrosis factor (TNF)-induced optic nerve degeneration in rats and examined the role of autophagy in this axon change process. In phosphate-buffered saline (PBS)-treated rat eyes, no sig...

Major pathological hallmarks of Alzheimer Disease are insoluble deposits of the short amyloid β-peptide (β-amyloid, Aβ), which is derived by sequential proteolytic cleavage from a large type I trans-membrane protein, the β-amyloid precursor protein (APP). APP is anterogradely transported by fast axonal transport in a distinct transport vesicle, but both the biochemical composition of such a ves...

Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury. Wallerian degeneration in the distal nerve stump contributes to the construction of a permissible microenvironment for peripheral nerve regeneration. To gain new molecular insights into Walleri...

PURPOSE To examine retinal ganglion cell (RGC) and axonal abnormalities in an ENU-induced mutant mouse carrying a protein-truncating nonsense mutation in OPA1. Mutations in the OPA1 gene cause autosomal dominant optic atrophy (ADOA) in which loss of RGCs followed by myelin degeneration in the optic nerve leads to progressive decrease in visual acuity. METHODS Ultrastructure of the optic nerve...

After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies show features characteristic of attempts to initiate the regenerative process of elongating the...