OBJECTIVES We aimed to determine whether ranirestat, an aldose reductase inhibitor, maintains the improved nerve function observed in patients with diabetic sensorimotor polyneuropathy (DSP) after completing a 12-week nerve biopsy study. RESEARCH DESIGN AND METHODS Patients with mild to moderate DSP, as determined by the presence of sural nerve responses, were enrolled in a double-blind, plac...

background : determining the validity of current median sensory nerve conduction techniques for diagnosis of carpal tunnel syndrome (cts). methods: eighty five patients with clinical diagnosis of cts were compared with the same number of healthy people. the validity of electrodiagnostic tests were compared in a case-control manner. these electrodiagnostictechniques included long-segment, short-...

BACKGROUND Electrodiagnostically, localization of ulnar nerve lesions, which commonly occurs at the elbow, is sometimes problematic. Measurement of motor ulnar nerve conduction velocity (NCV) at the elbow is amongst the most popular techniques to diagnose ulnar neuropathy. In this method, recording from the first dorsal interosseous muscle (FDI) is suggested to be more sensitive than the abduct...

OBJECTIVES Non-medical hospital staff members are in frequent contact with patients and therefore are required to perform a wide variety of repetitive and high-frequency activities. The objective of this study was to assess the relationships between upper extremity activity and carpal tunnel syndrome (CTS) among non-medical hospital staff members. MATERIAL AND METHODS Carpal tunnel syndrome i...

A deficiency in essential fatty acid metabolism has been widely reported in both human and animal diabetes. Fish oil supplementations (n-3 fatty acids), containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), were less effective on diabetic neuropathy than (n-6) fatty acids. This partial effect of (n-3) fatty acids might be attributed to the presence of EPA, a competitor of arach...

BACKGROUND Conventional methods in the diagnosis of carpal tunnel syndrome (CTS) in patients with polyneuropathy (PNP) are insufficient. AIMS We suggest that the comparison of the conduction of the median nerve with that of the neighboring peripheral nerves may be more beneficial in the diagnosis of entrapment neuropathy. SETTING AND DESIGN The median nerve sensory conduction in healthy vol...

BACKGROUND The purpose of this study is to report on the rehabilitative outcomes associated with common peroneal nerve (CPN) decompression and neurolysis revision when performed with open surgical implantation of a viable cryopreserved placental membrane (vCPM). METHODS Seven patients who underwent secondary CPN decompression and neurolysis with open surgical implantation of a viable cryopres...

OBJECTIVE Carpal tunnel syndrome (CTS) is a common median nerve entrapment neuropathy characterized by pain, paresthesias, diminished peripheral nerve conduction velocity (NCV) and maladaptive functional brain neuroplasticity. We evaluated structural reorganization in brain gray (GM) and white (WM) matter and whether such plasticity is linked to altered median nerve function in CTS. METHODS W...

AIMS To look for changes in nerve conduction velocity (NCV) in early stages of glucose intolerance, i.e. in impaired glucose tolerance (IGT) and in asymptomatic newly diagnosed Type 2 diabetic subjects (NDD). MATERIALS AND METHODS A total of 225 subjects were categorized as: Group 1: Subjects with normal glucose tolerance (NGT), Group 2: IGT subjects and Group 3: NDD subjects. Motor (MCV) and...

An 8 year old girl with partial duplication of the short arm of chromosome 17 had a mosaic 46,XX,der(17)?del(17)(p12)dup(17) (p11.2p12).ish dup(17)(p11.2p13.3)(D17S 379x2, p53x2, D17S122x2, D17S29+) karyotype. The extent of mosaicism was 20% in lymphoblasts and 100% in fibroblasts. Fluorescence in situ hybridisation (FISH) proved invaluable in defining the abnormality precisely. The cytogenetic...