Acknowledgement. We would like to thank Christopher Kello, Amber Story and Delcie Durham for helping to coordinate the work, and all the workshop participants for excellent contributions.

Nephrogenic systemic fibrosis (NSF) is a rare, idiopathic systemic fibrosing disorder that is predominantly characterized by a clinicopathologically distinct symmetric dermopathy and debilitating joint contractures. The condition affects patients with renal insufficiency and appears to show improvement with prompt restoration of renal function. Although NSF was initially reported in the United ...

BACKGROUND AND OBJECTIVES The pathogenesis of acquired nephrogenic systemic fibrosis recently described for patients with renal insufficiency and a history of exposition to gadolinium-based magnetic resonance contrast agents is not completely understood. A role for circulating fibroblasts in the fibrosing tissue is hypothetical, and the mechanism of the assumed trigger function of gadolinium re...

In classical Cell Biology, fundamental cellular processes are revealed empirically, one experiment at a time. While this approach has been enormously fruitful, our understanding of cells is far from complete. In fact, the more we know, the more keenly we perceive our ignorance of the profoundly complex and dynamic molecular systems that underlie cell structure and function. Thus, it has become ...

The manuscript by Schietinger et al. (1) in this issue of iJACC (JACC: Cardiovascular Imaging) assesses patterns of late gadolinium enhancement (LGE) in the myocardium of chronic hemodialysis patients. The observation that the majority of LGE was not infarct related but was tied to the degree of left ventricular hypertrophy, particularly in dysfunctional segments, led the authors to suggest tha...

BACKGROUND Nephrogenic systemic fibrosis (NSF) is a rare sclerosing skin condition associated with end-stage renal disease and gadolinium exposure. Therapy for NSF is challenging, with few options other than preventing exposure to gadolinium and improving renal function through transplant. However, in some cases neither of these options is tenable. We report the successful use of UV-A1 photothe...