intraocular metastatic tumors have been increasingly reported in the recent past. unlike choroidal metastasis, metastasis to retina is very rare and so far has been reported in very few case reports only. case presentation : a 56 year-old male who presented with a history of adenocarcinoma of the cecum and underwent lap colectomy for the primary cecal tumor, received adjuvant chemotherapy for a...

Appendiceal goblet cell adenocarcinomas (GCA) are rare entities with a distinctive composition of goblet, paneth and neuroendocrine cells. Cases combined or collision GCAs other appendiceal tumours exist in the literature, only few publications describing GCA low-grade mucinous neoplasm (LAMN). A 73-year-old female underwent right hemicolectomy following an orifice polypectomy showing adenocarc...

Recent years, the emerging new imaging techniques not only show the detailed and complete aspects of brain neoplasm, but also promote clinical doctors using new techniques, such as CT three-dimensional reconstruction, magnetic resonance spectroscopy (MRS), diffusion weighted imaging (DWI), diffusion tensor imaging (DTI) to research the mechanism of those diseases in the aim of better treatment....

Despite many years of research, a method to precisely and quantitatively determine cancer disease state remains elusive. Current practice for characterizing solid tumors involves the use of varying systems of tumor grading and staging and thus leaves diagnosis and clinical staging dependent on the experience and skill of the physicians involved. Although numerous disease markers have been ident...

Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA. Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fluorescently labeled DNA probe. Of these, using samples from 3 patients, 66% to...

The Gleason score (GS) plays an important role in prostate cancer detection and treatment. It is calculated based on a sum between its major and minor components, each ranging from 1 to 5, assigned after examination of sample cells taken from each side of the prostate gland during biopsy. A total GS of at least 7 is associated with more aggressive prostate cancer. However, it is still unclear h...

To investigate the expression of mutant p53 protein in workers occupationally exposed to benzidine, we detected mutant p53 protein by immuno-PCR assay in the serum of 331 benzidine-exposed healthy workers, while we classified exfoliated urothelial cells in urine samples with Papanicoloau's grading (PG). The Papanicoloau's grading classified exfoliated urothelial cells of the subjects from grade...

This article describes development of the Pecka Grading Rubric (PGR) as a strategy to facilitate and evaluate students' higher-order thinking in discussion boards. The purpose of this study was to describe psychometric properties of the PGR. Rubric reliability was pilot tested on a discussion board assignment used by 15 senior student registered nurse anesthetist enrolled in an Advanced Princip...

histological grading is a good parameter to stratify tumors according to their biological aggressiveness. the elston and ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. the aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. the samples included ...

Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiatin...