absract a case of 69- year-old woman with large pelvic mass and ascites is reported in this paper. with the exception of mild pelvic pain and a pelvic mass in pelvic , she had no symptom or sign . all routine and hormonal lab tests and tumor marker's were normal. the mri revealed a large mass in anterosuperior of uterus, and left ovary was situated in neighborhood of pelvic mass.her uterus norm...

Abstract Medulloblastoma (MB) is the most common malignant brain tumor affecting children. Among known subtypes of MB, GLI2-amplified SHH-MB associated with P53 mutations has worst prognosis, and a 5-year survival rate less than 30%. Moreover, MBs are non-responsive to SMO inhibitors, only targeted treatment option available for SHH-MB. To address this gap, there an urgent need identify novel p...

background: neonatal deaths mostly occur within the first one week and first 24 hours of life from a variety of conditions. objective: to examine the role of significant hypothermia and hypoglycaemia, in addition to some other factors, in neonatal mortality occurring within the first 24 hours of admission.methods: a prospective study of newborn infants hospitalized within the first 24 hours of ...

Spleen vascular tumors such as hemangiomas, albeit rare, can present during neonatal period with unexplained circulatory shock. We present a case of a newborn with refractory hypovolemic shock and acute abdomen that underwent emergency splenectomy due to spontaneous rupture of a splenic hemangioma.

Medulloblastomas are the most common malignant pediatric brain tumor and have been divided into four major molecular subgroups. Animal models that mimic the principal molecular aberrations of these subgroups will be important tools for preclinical studies and allow greater understanding of medulloblastoma biology. We report a new transgenic model of medulloblastoma that possesses a unique combi...

in 1991, handlers and colleagues described the central odontogenic fibroma (cof) as a distinct entity which is a rare benign odontogenic tumour and up to the present, only 78 cases of it have been published. cof usually occurs in an adult patient and has a predilection for the anterior region of the jaws. a 2.8:1 female to mail ratio is typically noted. this article presents a case of cof in a ...

A single subcutaneous injection of 20-methylcholanthrene into newborn AKR mice less than 24 hours old resulted in the acceleration of the development of lymphocytic leukemia, and induction of subcutaneous sarcomas and multiple-lung adenomas. Morphological descriptions of the respective tumors were given. It is suggested that the lungs of newborn mice of strain AKR may prove to be a sensitive or...

Adeno-associated viruses (AAV) are promising gene therapy vectors that have little or no acute toxicity. We show that normal mice and mice with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase. AAV proviruses were isolated from four tumors and were all located within a 6-kilobase region of chromosome ...

Although neonatal tumors are rare, neuroblastoma is the most common neoplasia among them. These tumors, which usually involve children in early infancy, are derived from neural crest cells of adrenal gland medulla or sympathetic ganglia. Even though congenital metastatic neuroblastoma presents a favorable prognosis, it may lead to death if not recognized and treated early on. The authors report...

Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable brain tumor that arises predominately in children and involves the pons, a structure that along with the midbrain and medulla makes up the brainstem. We have previously developed genetically engineered mouse models of brainstem glioma using the RCAS/Tv-a system by targeting PDGF-B overexpression, p53 loss, and H3.3K27M mutation to ...