role of NO in permeability changes of the blood-brain barrier in LPSinduced experimental meningitis (8 ). Another interesting potential explanation for the present observation is that lipopolysaccharide-s produced by gram-negative bacteria could induce local CRP synthesis in the central nervous system. CRP can be produced in neurons (9 ), and lipopolysaccharide-s can induce CRP in extrahepatic ...

To the Editor: Several reports have shown an ability of C-reactive protein (CRP) to discriminate between patients with bacterial meningitis and patients with aseptic (viral) meningitis (1, 2). Although a recent metaanalysis suggested that a negative CRP test in either cerebrospinal fluid (CSF) or serum can be used with a very high probability to rule out bacterial meningitis (3 ), a more recent...

background : meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. the similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. the aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of newbor...

Two infants, one premature and one full-term, died from meningitis due to Flav. meningosepticum type F. Careful bacteriological studies are required to prevent possible confusion with other Gram-negative bacilli which may cause meningitis in this age group.

Despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (BM) before organism growth in the culture medium-are missing. Therefore cerebrospinal fluid (CSF) lactate levels were evaluated as a possible means of differentiating the two clinical entities. This was a retrospective study....

Early-stage TB meningitis has no specific symptoms in patients, potentially leading to delayed diagnosis and consequently worsening prognosis. The authors present the fatal case with a delayed diagnosis of tuberculous (TB) meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection. The medical records, operative reports, and radiographical imaging studie...

meningitis, pneumonia, and sepsis in newborns and young infants (age < 60 days) are the main causes of childhood mortality in developing countries. even though streptococcus pneumonia is the most commonly detected microorganism in pediatric bacterial meningitis, it is rare in newborn infants. the following article reports a case of pneumococcal meningitis that was detected early in a newborn in...