A comparison of aerosol delivery has been made between two open-vent Pari jet nebulizers. Intermittent and continuous delivery were compared for one of the nebulizers. Ten healthy volunteers inhaled 99mTc-labelled diethylenetriamine penta-acetic acid (DTPA) aerosols on three occasions. The Pari LC device was operated both intermittently (by a manual interrupter that generated aerosol only in sy...

A new fully microwave-assisted liquid sample introduction system (MASIS) is presented and evaluated in Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES). The device employs a single TM010 microwave cavity for the simultaneous aerosol generation and desolvation. The different experimental requirements of both physical processes demand a careful system design and a judicious selec...

OBJECTIVES To evaluate the factors that affect nebulizer efficiency and to compare the relative cost effectiveness of nebulized medications used in the treatment of cystic fibrosis (CF), delivered by four types of disposable jet nebulizers that are widely used in hospitals. DESIGN The Hudson 1730 Updraft II, Baxter Misty-Neb, Marquest Whisper Jet (WJ), and Marquest Acorn II were evaluated in ...

The increase in forced expiratory volume in one second (FEV1) seen in asthmatics after inhalation of isotonic saline was studied in a blind, cross-over investigation of 24 consecutive out-patients presenting with reversible chronic airway obstruction. Forced expiratory manoeuvres allowing the measurement of FEV1 and forced vital capacity (FVC) were performed at six time intervals during a perio...

The European Respiratory Society (ERS) recognizes that there are an increasing number of national and international guidelines for the management of asthma, chronic obstructive pulmonary disease (COPD) and other chest diseases. Some of these guidelines recommend nebulizer use in specific circumstances, using either a jet nebulizer or an ultrasonic nebulizer to administer a drug to the airways o...

STUDY OBJECTIVES The function of jet nebulizers has been measured traditionally by gravimetric methods, i.e., by weighing nebulizers before and after nebulization. Newer techniques measure aerosol output directly by analyzing aerosolized drug or tracer, i.e., radioactive 99mTc. Because of evaporation, the equivalence of these methods is uncertain. The aim of this study was to determine if the g...

A low flow, parallel path Mira Mist CE nebulizer designed for capillary electrophoresis (CE) was evaluated as a function of make-up solution flow rate, composition, and concentration, as well as the nebulizer gas flow rate. This research was conducted in support of a project related to the separation and quantification of cobalamin (vitamin B-12) species using microseparation techniques combine...

In this issue of RESPIRATORY CARE, Ball and colleagues1 determined the optimal nebulizer configurations and positions for aerosol delivery in vitro with and without CPAP. They determined that with continuous high-flow CPAP, the greatest amount of albuterol delivered to a lung simulator (13.8 4.4%) was when the nebulizer was placed proximal to the lung simulator. Without CPAP, they determined th...

BACKGROUND The primary focus of previous aerosol research during mechanical ventilation was the endotracheal tube (ETT). Consequently, there are limited data in the literature on the delivery of inhaled medications administered with different aerosol devices in mechanically ventilated patients with a tracheostomy tube (TT). The purpose of this study was to quantify and compare the efficiency of...

The objective of this study was to determine whether current regulatory methods for assessing the output of nebulizers are appropriate for the delivery of nebulized steroid suspensions to patients. We studied a conventional jet nebulizer (the Intersurgical Cirrus), an open-vent nebulizer (the Medicaid Sidestream) and a breath-enhanced nebulizer (the Pari LC Plus), using a constant sampling flow...