Diabetes impairs the microcirculation and function of various vital tissues throughout the body. The conjunctival microcirculation can be non-invasively imaged and thus enables assessment of microvascular hemodynamics. In this study, alterations in conjunctival microvascular hemodynamics were quantitatively assessed at stages of increasing diabetic microvasculopathy based on diabetic retinopath...

The problem of multiple comparisons has become increasingly important in light of the significant increase in volume of data available to statisticians. The seminal work of Benjamini and Hochberg (1995) on the control of the false discovery rate (FDR) has brought forth an alternative way of measuring type I error rate that is often more relevant than the one based on the family-wise error rate....

The morphology and polarized growth of cells depend on pathways that control the asymmetric distribution of regulatory factors. The evolutionarily conserved Ndr kinases play important roles in cell polarity and morphogenesis in yeast and invertebrates but it is unclear whether they perform a similar function in mammalian cells. Here, we analyze the function of mammalian Ndr1 and Ndr2 (also know...

Hexagonal boron nitride (hBN) is drawing increasing attention as an insulator and substrate material to develop next generation graphene-based electronic devices. In this paper, we investigate the quantum transport in heterostructures consisting of a few atomic layers thick hBN film sandwiched between graphene nanoribbon electrodes. We show a gate-controllable vertical transistor exhibiting str...

OBJECTIVE The purpose of this study was to evaluate the reliability and quality of radiomic features in glioblastoma multiforme (GBM) derived from tumor volumes obtained with semi-automated tumor segmentation software. MATERIALS AND METHODS MR images of 45 GBM patients (29 males, 16 females) were downloaded from The Cancer Imaging Archive, in which post-contrast T1-weighted imaging and fluid-...

BACKGROUND The nuclear Dbf2 related (NDR) family of protein kinases play important roles in cell-cycle regulation, apoptosis, cell morphogenesis, and development in a variety of organisms. In budding yeast, the NDR kinase complex composed of Cbk1 and its regulatory subunit, Mob2, have an established role in the control of cell separation/abscission that follows cytokinesis. Whereas the activato...

Quantum transport properties of pure and functioned infinite lead-connection region-lead systembased on the zigzag graphene nanoribbon (2-zGNR) have been investigated. In this work the effectof the doping functionalization on the quantum transport of the 2-zGNR has been computationallystudied. Also, the effect of the imposed gate voltages (-3.0, 0.0 and +3.0 V) and bias voltages 0.0 to2.0 V hav...

The intent of this document is to be a brief overview of the current state of collections and associated processing/representation in the NDR. The hope is to convey a general understanding of the current collections architecture as it stands, as well as any advantages, limitations, and not-so-obvious design decisions that were made. It seems appropriate to start by explaining how data in collec...

Pankaj Sharma, Laurent Syavoch Bernard, Antonios Bazigos, Arnaud Magrez and Adrian M. Ionescu École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland [email protected] Abstract Negative differential resistance (NDR) is a phenomenon in which an increase in voltage across the device's terminals results in a decrease in electric current through it. This is in contrast to a resist...

One of the interesing tunneling phenomena is negative differential resistance (NDR), the basic principle of resonant-tunneling diodes. NDR has been utilized in various semiconductor devices such as frequency multipliers, oscillators, relfection amplifiers, logic switches, and memories. The NDR in graphene has been also reported theoretically as well as experimentally, but should be further stud...