نتایج جستجو برای: ncx3

تعداد نتایج: 85  

2017
Lauriane Y. M. Michel Sjoerd Verkaart Werner J. H. Koopman Peter H. G. M. Willems Joost G. J. Hoenderop René J. M. Bindels

Journal: :The Chinese journal of physiology 2017
Pi-Cheng Cheng Ya-Shuan Chen Rong-Chi Huang

The plasmalemmal Na⁺/Ca²⁺ changer (NCX) regulates intracellular Ca²⁺ by exchanging 3 Na⁺ for 1 Ca²⁺ in either the Ca²⁺ exit or Ca²⁺ entry mode. All three NCX isoforms NCX1, NCX2, and NCX3 are expressed in the rat brain, with isoform-specific differential distribution. In the central clock of suprachiasmatic nucleus (SCN), intracellular Ca²⁺ controls the circadian release of major neuropeptides,...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Lisann Pelzl Zohreh Hosseinzadeh Kousi Alzoubi Tamer Al-Maghout Sebastian Schmidt Christos Stournaras Florian Lang

BACKGROUND/AIMS According to previous observations, enhanced store-operated Ca2+-entry (SOCE) accomplished by the pore forming ion channel unit Orai1 and its regulator STIM1 contribute to therapy resistance of ovary carcinoma cells. Ca2+ signaling is further shaped by Ca2+ extrusion through K+-independent (NCX) and/or K+-dependent (NCKX) Na+/Ca2+-exchangers. The present study thus explored whet...

2010
Anna-Karin Persson Joel A Black Andreas Gasser Xiaoyang Cheng Tanya Z Fischer Stephen G Waxman

BACKGROUND Nociception requires transduction and impulse electrogenesis in nerve fibers which innervate the body surface, including the skin. However, the molecular substrates for transduction and action potential initiation in nociceptors are incompletely understood. In this study, we examined the expression and distribution of Na+/Ca2+ exchanger (NCX) and voltage-gated sodium channel isoforms...

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