Titanium has an osseointegrative property, while hydroxyapatite has an osteoconductive property. It remains a matter of controversy among researchers whether hydroxyapatite has higher osteoblast compatibility than titanium. Here, we compared the activities between osteoblasts cultured on titanium and those cultured on hydroxyapatite. An osteoblast-like cell line, MC3T3-E1, was cultured on machi...

objective(s):  although several chemical and physical methods for gene delivery have been introduced, their cytotoxicity, non-specific immune responses and the lack of biodegradability remain the main issues. in this study, hydroxyapatite nanoparticles (nps) and 1,2-dioleoyl-sn-glycero-3-phosphoethanol​amine (dope)-modified hydroxyapatite nps was coated with antisense oligonucleotide of e6 mrna...

This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment. The synthetic process and morphology of hydroxyapatite were reported. The effects of hydroxyapatite content on the microstructure and mechanical properties of composites were investigated. It was found that the Y...

Bone like hydroxyapatite (nHAp) was synthesized via an in situ biomimetic process in presence of wheat starch. The effect of polymer concentration alteration on the final structure of nHAp was investigated. Formation of the nHAp at room temperature was confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Size and morphology of the nHAp samples were character...

New materials that mimic natural bone properties, matching functional, mechanical, and biological properties have been continuously developed to rehabilitate defects. Desirably, ‘tissue engineering’ has a multidisciplinary ground uses the principles of life sciences engineering for replacements restore or replace tissue function whole organ. Nevertheless, grafting treatment numerous restriction...

static bone scan was performed in 46 patients for evaluation of ocular hydroxyapatite vascularization. study findings indicated that bone scan, with tc-99m mdp is an appropriate method for evaluation of hydroxyapatite vascularization and for estimating the time for peg insertion into the hydroxyapatite implant. our study showed proper hydroxyapatite vascularization when the ratio of activity in...

The remarkable stoichiometric flexibility of hydroxyapatite (HAp) enables the formation of a variety of charged structural sites at the material's surface which facilitates bone remodeling due to binding of biomolecule moieties in zwitterionic fashion. In this paper, we report for the first time that an optimized biomedical grade silicon nitride (Si3N4) demonstrated cell adhesion and improved o...

Fishbone comprising hydroxyapatite (bio-ceramic) is regularly viewed as a natural resource for biological and pharmaceutical applications. In this study, has been prepared from fishbone waste using thermal calcination method. The composite hydroxyapatite–montmorillonite–sodium alginate was synthesized by co-precipitation Various functional groups of biocomposite were characterised Fourier trans...