Unfortunately, whilst the in vitro evidence for their beneficial effects on lipid profile is convincing, this does not translate with any compelling degree into prevention of primary cardiovascular events. Except in borderline normo/hypercholesterolaemia, prescription drugs (eg, statins) are more effective than stanol/sterol esters for lowering LDL cholesterol. The National Institute for Health...

The concept of multimorbidity has attracted growing interest over recent years, and more latterly with the publication of specific guidelines on multimorbidity by the National Institute for Health and Care Excellence (NICE). Increasingly it is recognised that this is of particular relevance to practitioners caring for older adults, where multimorbidity may be more complex due to the overlap of ...

A routine part of the process for developing National Institute for Health and Care Excellence (NICE) medical technologies guidance is a submission of clinical and economic evidence by the technology manufacturer. The Birmingham and Brunel Consortium External Assessment Centre (EAC; a consortium of the University of Birmingham and Brunel University) independently appraised the submission on the...

Psychological and pharmacological modalities have been proposed by studies to be adapted for treatment of panic disorder. Selective Serotonin Receptor Inhibitors (SSRI), a group antidepressant is the first-line drug recommended National Institute Health Care Excellence (NICE) British Association Psychopharmacology their more desired profile adverse effect over other classes antidepressants such...

community. BMJ 1997;314:667-9. 8 National Institute for Clinical Excellence.Anakinra for rheumatoid arthritis. London: NICE, 2003. (Technology appraisal No 72.) www.nice.org.uk/ page.aspx?o = 94670 (accessed 25 Jun 2004). 9 National Institute for Clinical Excellence. Beta interferon and glatiramer acetate for the treatment of multiple sclerosis. London: NICE, 2002. (Technology appraisal No 32.)...

Clinical guidelines are developed by professional societies and also, in England, an independent non-departmental public body, the National Institute for Health Care Excellence (NICE). Similarities differences between these should be viewed context of different objectives, responsibilities roles guideline developers. This review describes NICE clinical development principles processes with aim ...

Hypothesis / aims of study Clinical audit is a quality improvement process that seeks to improve patient care and outcome. The audit cycle consists of systematic review of care against explicit criteria, implementation of change and finally,a re-audit to complete the audit cycle. TVT was introduced in our institute in 2001. In 2003, The National Institute of Clinical Excellence (NICE) published...