BACKGROUND Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is completely unknown. METHODS We studied light chain 3 (LC3) protein expression...

Introduction: Nasal polyps are pedunculated, edematous, prolapsed mucosa of the paranasal sinuses. These polyps commonly arise around the ostia of the paranasal sinuses in the middle meatus. Discussion: The commonest sites of polyp formation are the ethmoid sinuses and maxillary sinus. Rarely polyps may also arise from the other paranasal sinuses. Sites in the nasal mucosa other than the parana...

Introduction: Chronic rhinosinusitis (CRS) with nasal polyps is a common form of the disorder with distinct immunopathology and significant impact on the healthrelated quality of life of patients. Several treatment options—depending on the clinical course and severity of the disease—have been recommended, from medical therapy with oral or topical corticosteroids to various methods of surgical m...

OBJECTIVE To investigate whether cystic fibrosis (CF)-related nasal polyps exhibit significantly distinct glycohistochemical characteristics when compared with single vs massive nasal polyps obtained from patients without CF. DESIGN Glycohistochemical characteristics were identified by means of 8 histochemical probes, including 5 plant lectins (peanut, gorse seed, wheat germ, Maackia amurensi...

background: nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation.  the role of allergy and ige in pathogenesis of nasal polyps is still unclear.  ige receptors are important components of the immunological pathway in allergic and inflammatory diseases.   objective: to determine if the low affinity ige receptor (cd23) is presented on nasal polyp t...

BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease; the underlying mechanisms of cell signalling are not fully understood. STAT3 (signal transducer and activator of transcription 3) is a phosphokinase and a key signalling molecule implicated in cell cycle regulation. We studied the distribution and expression of STAT3 to examine the role of STAT3 in the pat...

We conducted a retrospective study to determine the prevalence of Samter's triad (nasal polyps, asthma, and aspirin sensitivity) in 208 consecutively presenting patients who had undergone functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis from September 2001 through August 2003. Overall, Samter's triad was found in 10 patients (4.8%); subgroup analyses showed that the prevale...

Nasal polyps are benign oedematous outgrowths of respiratory mucosa which frequently present to the clinician as a cause of nasal obstruction. Though nasal and sinus polyps are not true neoplasms, long -standing inflammation can lead to metaplastic changes on the surface of the mucosa, and occasionally even to carcinoma. We report a case who presented with typical findings of nasal polyposis, b...

It is often considered that where nasal obstruction can be attributed to the presence of nasal polyps that the diagnostic process is at an end. The fact that the majority of simple nasal polyps are benign reinforces this view. Linked with this, the fact that the majority of serving soldiers are healthy, may lead the unwary into not suspecting some of the other types of nasal polyp.

Background : To compare the effectiveness of topical steroid and oral steroid in reducing size of polyps and improving patency of nasal air way. Methods: In this randomized controlled trial a total of 140 patients were taken with bilateral nasal polypi. They were divided in 2 groups. Group A (70 ) were given topical steroids and Group B (70) were given oral steroids. Patients aged above 15 year...