BACKGROUND Nasal polyposis is characterized by persistent inflammation but the pathogenesis is complex and still debatable. Autophagy has been associated with many human health problems including chronic inflammatory airway diseases. Whether autophagy plays a role in nasal polyps and could be a therapeutic target is completely unknown. METHODS We studied light chain 3 (LC3) protein expression...

OBJECTIVE To analyze the immunological pattern of nasal polyposis in patients with and without allergy, the percentages of CD4+ cells expressing intracellular interferon-gamma and interleukin-4 (T helper [T(H)] type 1 and 2 cells) were measured by flow cytometry in samples from patients with nasal polyps. METHODS Samples from 32 patients (16 atopic, 16 nonatopic) were studied. The fresh nasal...

OBJECTIVES This study aims to investigate the possible role of non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in nasal polyp development. PATIENTS AND METHODS Twenty-one patients (15 males, 6 females; mean age 44.3 years; range 16 to 65 years) who underwent endoscopic sinus surgery for nasal polyposis (NP) were included in the study. Inferior turbinate mucosa samples were taken...

BACKGROUND Nasal polyposis is characterized by impaired regulation of nasal tissue growth and is associated with chronic inflammation, sinus infections, and low levels of nitric oxide (NO). Based on its critical role in mediating cell growth and antimicrobial function, decrease of NO levels has been implicated in the pathogenesis of nasal polyposis. OBJECTIVE We sought to evaluate mechanisms ...

Although choanal polyps frequently arise from the maxillary sinus, a choanal polyp originating from the inferior turbinate is a rare entity. A 14-year-old girl who had a history of bilateral nasal obstruction with snoring, mouth breathing and nasal discharge for 10 years was presented. On endoscopic examination, a polypoid mass completely obliterated the right nasal cavity. The left choana was ...

INTRODUCTION An Antrochoanal polyp, or Killian's polyp is a benign solitary polypoid lesion that affects mainly children and young adults. Studies demonstrate that Killian's polyp generally represents 4-6% of all nasal polyps. However, in the pediatric population this percentage reaches 33%. It originates from a hypertrophy of the mucous membrane on the maxillary sinus antrum, and it grows for ...

INTRODUCTION Nasal polyps are benign prolapsed mucosal lesions which commonly arise from the paranasal sinuses and lateral walls of the nose especially the contact areas of osteomeatal complex. Though nasal polyps arising from the nasal septum have been reported, those arising from its anterior part are extremely rare and present a diagnostic dilemma. Aetiology is multifactorial and is mainly a...

Nasal polyp is a non neoplastic lesion of the respiratory mucosa. In few cases, it can be possible to detech presence cholesterolgranuloma. We present case 55 year-old patient affected by nasal lesion, localized in sphenoethmoidal recess, with particular microscopic feature and review literature.

Antrochoanal polyps usually present unilaterally. It is defined as a polyp originating in the maxillary sinus, protruding in the middle meatus through the ethmoidal infundibulum or an accessory ostium and further extends posteriorly through the choana into the nasopharynx or in oropharynx in a few cases. An antrochoanal polyp usually has three parts according to its extension, i.e antral, nasal...

BACKGROUND Nasal polyposis (NP) is a chronic inflammatory disease of the upper airways, that characterized by inflammatory cells infiltration, extracellular matrix accumulation and oedema. Interleukin-6 (IL-6) is a multifunctional cytokine, implicated in various inflammatory conditions, including NP pathogenesis. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory mediator able t...