نتایج جستجو برای: naproxen

تعداد نتایج: 2312  

Journal: :Molecules 2017
Mohammad Najlah Sally Freeman Mouhamad Khoder David Attwood Antony D'Emanuele

The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conju...

Journal: :Annals of the rheumatic diseases 2005
L S Lohmander D McKeith O Svensson M Malmenäs L Bolin A Kalla G Genti J Szechinski C Ramos-Remus

OBJECTIVE To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS 970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The primary end point was the six week incidence of endoscopic gastroduodenal ulcer...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
M Josa J P Urizar J Rapado C Dios-Viéitez G Castañeda-Hernández F Flores-Murrieta M J Renedo I F Trocóniz

Pharmacokinetic/pharmacodynamic modeling was used to characterize the antipyretic and anti-inflammatory effects of naproxen in rats. An indirect response model was used to describe the antipyretic effects of naproxen after short intravenous infusions. The model assumes that basal temperature (T(a)) is maintained by the balance of fever mediators given by a constant (zero order) rate of synthesi...

Journal: :Archives of pharmacal research 2010
Mario I Ortiz Martha L Ramírez-Montiel Martha P González-García Héctor A Ponce-Monter Gilberto Castañeda-Hernández Raquel Cariño-Cortés

It has been shown that the association of non-steroidal anti-inflammatory drugs with plant extracts can increase their antinociceptive activity, allowing the use of lower doses and, thus, limiting side effects. Therefore, the aim of this study was to examine the effects of the interaction between naproxen and citral on nociception and gastric injury in rats. Naproxen, citral, or combinations of...

Journal: :BMC Family Practice 2002
Eduardo Collantes Sean P Curtis Ka Wing Lee Noemi Casas Timothy McCarthy Agustin Melian Peng L Zhao Diana B Rodgers Calogera L McCormick Michael Lee Christopher R Lines Barry J Gertz

BACKGROUND Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the treatment of rheumatoid arthritis (RA). METHODS Double-blind, randomized, placebo and active comparator-controlled, 12-week study conducted at 67 sites in 28 countries. Eligible patients were chronic NSAID users who demonstrated a clinical worsening of arthritis upon withdrawal of prestudy NSAIDs. Patients...

Journal: :The American journal of gastroenterology 1995
J M Scheiman P M Patel E K Henson T T Nostrant

OBJECTIVES Gastrointestinal symptoms, particularly pyrosis, complicate nonsteroidal anti-inflammatory drug (NSAID) use. NSAIDs cause esophageal injury, and H2 blockers are often prescribed for, and successfully control, NSAID-related symptoms. To determine whether NSAIDs can induce gastroesophageal reflux, we studied the effect of a commonly used NSAID, naproxen, on reflux parameters and esopha...

Journal: :iranian journal of pharmaceutical sciences 0
maryam maghsoodi school of pharmacy and drug applied research center, tabriz university of medical sciences, tabriz, iran sara esmaeilzadeh school of pharmacy and drug applied research center, tabriz university of medical sciences, tabriz, iran

in this study, the effect of recrystallization of naproxen in the presence of hydroxypropyl cellulose (hpc) on the release rate of drug was investigated. crystals were generated by the anti-solvent approach using the hpc solution in water as the anti-solvent. the samples were subjected to various physicochemical evaluations such as crystal size, scanning electron microscopy, fourier transform i...

2016
Margaret N. Essex Michael A. O'Connell Regina Behar Weihang Bao

AIM To compare the efficacy, tolerability and safety of celecoxib, naproxen and placebo in Asian patients with osteoarthritis (OA) of the knee. METHOD Patients of Asian descent with knee OA, aged ≥ 45 years, in a flare state with a functional capacity classification of I-III, received celecoxib 200 mg once daily, naproxen 500 mg twice daily or placebo, for 6 weeks. The change in Patient's Ass...

2016
Eva Balazcs Joachim Sieper Kara Bickham Anish Mehta Nancy Frontera Paul Stryszak Zoran Popmihajlov Paul M. Peloso

BACKGROUND This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS). METHODS This was a 2-part, double-blind, active comparator-controlled non-inferiority study in subjects ≥18 years of age with AS. In Part I, subjects were randomized to naproxen 1000 mg; etoricoxib 60 mg, and 90 mg. In Part II, naproxen and etoricoxib 90 mg...

Journal: :Evidence-based nursing 2005
Tracey Bucknall

Mason L, Edwards JE, Moore RA, et al. Single dose oral naproxen and naproxen sodium for acute postoperative pain. Cochrane Database Syst Rev 2004;(4):CD004234. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

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