The rate of dissolution of drugs remains one of the most challenging aspects in formulation development of poorly water-soluble drugs. The meloxicam, a low molecular analgetic for oral administration, exhibits a slow dissolution. To improve the dissolution rate, the drug was formulated in a nanosuspension by using an emulsion-diffusion method, high-pressure homogenization or sonication. Optimiz...

The development of a catalytic chemiluminescent trimethylamine (TMA) sensor is demonstrated in the present paper. Intensive chemiluminescence (CL) is detected when TMA is introduced over the surface of nanosized catalysts and subsequently catalytically oxidized by O(2) from the air, and four catalysts are investigated with the strongest CL intensity obtained on nanosized Y(2)O(3). This effect i...

MoS(2)@CMK-3 nanocomposite consisting of confined nanosized MoS(2) in CMK-3 carbon matrix exhibits much improved cycling performance and rate capability due to the enlarged interlayer distance and favorable conductivity.

Nanosized titanium dioxide (nano-TiO2) particles are used in diverse products and devices, including photocatalytic water splitting and solar cells whose successful commercialization is still facing scientific and technologi-

Nanosized spherical LiFePO4/C composite was synthesized from nanosized spherical FePO4 ·2H2O, Li2C2O4, aluminum oxide, titanium oxide, oxalic acid, and sucrose by binary sintering process. The phases and morphologies of LiFePO4/C were characterized using SEM, TEM, CV, EIS, EDS, and EDX as well as charging and discharging measurements. The results showed that the as-prepared LiFePO4/C composite ...

Despite their good intrinsic rate capability, nanosized spinel cathode materials cannot fulfill the requirement of high electrode density and volumetric energy density. Standard carbon coating cannot be applied on spinel materials due to the formation of oxygen defects during the high-temperature annealing process. To overcome these problems, here we present a composite material consisting of a...

The EU Regulation on Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) demands the implementation of alternative methods for analyzing the hazardous effects of chemicals including particulate formulations. In the field of inhalation toxicology, a variety of in vitro models have been developed for such studies. To simulate the in vivo situation, an adequate exposure de...

Although our understanding of RNAi and our knowledge on designing and synthesizing active and safe siRNAs significantly increased during the past decade, targeted delivery remains the major limitation in the development of siRNA therapeutics. On one hand, practical considerations dictate robust chemistry reproducibly providing precise carrier molecules. On the other hand, the multistep delivery...