نتایج جستجو برای: nanoconjugate

تعداد نتایج: 106  

Journal: :Journal for ImmunoTherapy of Cancer 2021

Background Anti-inflammatory (M2) tumour-associated macrophages (TAMs) exert protumoural roles through angiogenesis, immunosuppression and resistance to therapies. 1 M2 TAMs express the mannose receptor, CD206, 2 excellent marker for targeted We have previously identified a peptide called mUNO that specifically binds CD206 on TAMs. Aiming dissect role of high in tumour progression immunosuppres...

2010
Sang Van Sanjib K Das Xinghe Wang Zhongling Feng Yi Jin Zheng Hou Fu Chen Annie Pham Nan Jiang Stephen B Howell Lei Yu

The purpose of this study was to develop a novel, highly water-soluble poly(L-γ-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel (PTX). PGG-PTX is a modification of poly(L-glutamic acid)- paclitaxel conjugate (PGA-PTX) in which an additional glutamic acid has been added to each glutamic side chain in the polymer. PGG-PTX has higher wa...

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