Abstract Extraction from the herbs was performed using Soxhlet method. Various formula synthesized for niosomes containing extracts through thin film synthesis technique, and most efficient formulation selected. Afterwards, physicochemical properties of niosomes, including size, polydispersity index (PDI), zeta potential, morphology, encapsulation efficacy (EE%), extract release rate, non-inter...

Niosomes are a novel drug delivery system, in which the medication is encapsulated vesicle. The vesicle composed of bilayer non-ionic surfactants. mostly preferred than liposomes because they stable and cost effective. potentiate pharmacological action molecules by delaying clearance from circulation, protecting biological environment restricting effects only to target cells. In it has applicat...

Magnetism has wide applications in various fields, such as diagnostics, drug targeting, molecular biology, cell isolation, cell purification, hyperthermia, and radioimmunoassay. In this study, we synthesized niosomes doped with iron oxide nanoparticles and a fluorophore for potential applications in magnetically targeted drug delivery. Release kinetics of the fluorophore and cytotoxicity were a...

Innovative niosomes made up of α,ω-hexadecyl-bis-(1-aza-18-crown-6) (bola), Span 80® and cholesterol (2:5:2 molar ratio) are proposed as suitable delivery systems for the administration of 5-fluorouracil (5-FU), an antitumoral compound largely used in the treatment of breast cancer. The bola-niosomes, after sonication procedure, showed mean sizes of ~200 nm and a loading capacity of ~40% with r...

PURPOSE A niosome based transdermal drug delivery system of Nimesulide (NIM) was developed and extensively characterized and evaluated for in-vitro performance followed by in-vivo evaluation in rats by carrageenan induced rat paw edema method. METHOD Niosomes were prepared by lipid film hydration technique using tweens and spans. Preparation of niosomes was optimized for highest percent drug ...

Synthetic nonionic surfactant vesicles (niosomes) are a colloidal system with closed bilayer structures, displaying distinct advantages in stability and cost compared with liposomes. In this article, polysorbate cationic niosomes (PCNs) were developed as gene carriers. The PCNs comprised nonionic surfactants (i.e., polysorbates) and a cationic cholesterol, and were synthesized using a film hydr...

The aim and objective of the study was to develop herbal drug loaded niosomes as topical gel by using thin film hydration technique. The practicability of herbal drug (CODE: THDC3-2615RD) of niosomes by thin film hydration technique using Span series 20, 60, 80 and cholesterol has been successfully revealed in this study. The evolved herbal niosomes were evaluated for morphology, particle size ...

Highly stable niosomes are prepared and investigated in Tween80/PEG6000/Span80/H2O system. The mean radius of the niosomes is 0.15-0.2 microm. The contents of PEG6000 and Span80 and the system temperature affect the size and the stability of the niosome. A certain Span80 can remarkably improve the stability. The niosome is provided distinctly with the hydrotrope-solubilization action to the hyd...

Objective: Niosomal gel formulations containing phenytoin sodium have been prepared for enhancing skin wound healing. Methods: Solvent evaporation-film hydration methodology was adopted for noisome formation. Different compositions of phenytoin, surfactant and cholesterol were tested. The prepared niosomes were evaluated for size of vesicles, drug entrapment efficiency and release profiles. Res...