Naloxone is a non-selective, short-acting opioid receptor antagonist that has a long clinical history of successful use and is presently considered a safe drug over a wide dose range (up to 10 mg). In opioid-dependent patients, naloxone is used in the treatment of opioid-overdose-induced respiratory depression, in (ultra)rapid detoxification and in combination with buprenorphine for maintenance...

In order to test the hypothesis that endogenous opiates are at least partially responsible for hyperinsulinaemia in patients with polycystic ovarian disease (PCOD), the effect of naloxone (an opiate receptor blocker) on the insulin response to oral glucose load (OGTT) was studied in 20 women with PCOD and 17 control subjects at days 5-8 of their follicular phase. After fasting overnight for 10-...

INTRODUCTION Naloxone is a medication that is frequently administered in the field by paramedics for suspected opioid overdoses. Most prehospital protocols, however, require this medication to be given to patients intravenously (i.v.) or intramuscularly (i.m.). Unfortunately, intravenous line placement may be problematic and time-consuming in chronic i.v. drug users. There may also be a delay i...

An oral, fixed-dose combination of prolonged-release (PR) oxycodone with PR naloxone (Targin(®), Targiniq(®), Targinact(®); hereafter referred to as oxycodone/naloxone PR) is approved in Europe for the second-line symptomatic treatment of patients with severe to very severe idiopathic restless legs syndrome (RLS), after failure of dopaminergic therapy. Coadministration of naloxone represents a ...

Naloxone is a medication that reverses respiratory depression from opioid overdose if given in time. Paramedics routinely administer naloxone to opioid overdose victims in the prehospital setting, and many states are moving to increase access to the medication. Several jurisdictions have expanded naloxone administration authority to nonparamedic first responders, and others are considering that...

Extracellular and intracellular microelectrode studies were conducted to test the actions and interactions of naloxone and naltrexone, two supposedly "pure" opiate antagonists. Both were shown to depress excitability and action potential production when applied in relatively high concentrations. Low naltrexone concentrations antagonized the depression produced by naloxone, but low naloxone conc...

BACKGROUND Availability of the opioid antagonist naloxone for lay administration has grown substantially since first proposed in 1996. Gaps remain, though, in our understanding of how people who inject drugs (PWID) engage with naloxone programmes over time. AIMS This paper aimed to address three specific evidence gaps: the extent of naloxone supply to PWID; supply-source (community or prisons...

INTRODUCTION The standard of care for reversal of opioid-induced respiratory depression associated with opioid overdose is injectable naloxone. This study compared the usability of two naloxone delivery devices, a naloxone auto-injector (NAI) and a naloxone intranasal delivery system (NXN), in the administration of naloxone during a simulated opioid overdose emergency. NAI (EVZIO (®) ; kaleo, I...

Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, nitrergic systems in mice. Methods: A total 340 male mice were randomly divided into 2 categories. Each category included four experiments groups. In ...

Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. A number of 124 patients with the diagnosis of tramadol overdose were divided to receive low-do...