Only recently, with the identification of antibodies to a 43-kDa muscle autoantigen, subsequently identified as cytoplasmic 50-nucleotidase 1A (cN1A) in sera from patients with inclusion body myositis (IBM), has a role for B-cell autoimmunity in IBM been demonstrated. IgG antibodies to cN1A have> 90% specificity and 34%–70% sensitivity in IBM. Detection of all 3 isotypes (IgG, IgM, and IgA) by ...

The common bed bug is an obligate hematophagous parasite of humans. We studied the regulation of molting and metamorphosis in bed bugs with a goal to identify key players involved. qRT-PCR studies on the expression of genes known to be involved in molting and metamorphosis showed high levels of Krüppel homolog 1 [Kr-h1, a transcription factor that plays key roles in juvenile hormone (JH) action...

Herein, direct production of hydrogen peroxide (H2O2) through hydroxylamine (NH2OH) oxidation by molecular oxygen was greatly enhanced over modified activated carbon fiber (ACF) catalysts. We revealed that the higher content pyrrolic/pyridone nitrogen (N5) and carboxyl-anhydride could effectively promote selectivity yield H2O2. By changing volume ratio concentrated H2SO4 HNO3, N5 surface contai...

Quaternary ammonium compounds are known to highly concentrate in articular cartilages after i.v. administration. This property was used to synthesize new potential radiodiagnostic agents for joint imaging. Pharmacokinetic study was performed in rats for three new compounds: N-pyridinium-propyl-cyclam (NPPC), N-triethylammonium-propyl-cyclam (NTPC), and N-[triethylammonium]-3-propyl-[15]ane-N5 (...