Tyrosinase, which usually catalyzes the conversion of o-diphenols to o-benzoquinones, catalyzed an unusual oxidative dimerization of 1,2-dehydro-N-acetyldopamine to a benzodioxan derivative. The identity of the product was confirmed by UV, IR spectra, and NMR studies. During the oxidation, generation of a transient reactive intermediate could be witnessed by its characteristic visible absorptio...

The first studies were published on the possible pathogenetic role of so-called ectopically localized taste receptors in bronchial asthma. for bitter and sweet taste, may, apparently, have opposite functions, but available literature there is no data balance sensitivity tastes same patients with aim present work to simultaneously assess canonical lingual different clinical variants asthma by me...

derivatives of thiazolidinone ring systems are known to act as anti-hiv infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...

Thioureas are oxygenated by flavin-containing monooxygenases (FMOs), forming reactive sulfenic and/or sulfinic acids. Sulfenic acids can reversibly react with GSH and drive oxidative stress through a redox cycle. For this reason, thiourea S-oxygenation is an example of FMO-dependent bioactivation of a xenobiotic. Functional FMO2 is expressed in the lung of 26% of individuals of African descent ...

The black pigment cells in the skin, iris, and retina of Eleutherodactylus martinicensis (Tschudi) are melanophores. Under the influence of c o 1 per cent, phenylthiourea the melanin disappears in about 84 hours at laboratory temperatures. After administration of the substance for 5 days, discontinuance of treatment is followed by return of the pigment within 72 hours, to an extent at least equ...