A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

An atom-economic synthetic route to benzimidazolium salts is presented. The annulated polycyclic systems: 1,3-bis(2,4,6-trimethylphenyl)-1H-benzo[d]imidazol-3-ium chloride (1-Cl), 1,3-bis(2,6-diisopropylphenyl)-1H-benzo[d]imidazol-3-ium chloride (2-Cl), 1,3-diphenyl-1H-benzo[d]imidazol-3-ium chloride (3-Cl), and 1,3-di(pyridin-2-yl)-1H-benzo[d]imidazol-3-ium chloride (4-Cl) were prepared in a t...

Bis-benzimidazole diamide ligand, 3,3'-thiobis-(N-((1H-benzo[d]imidazol-2-yl)methyl) propanamide [GBTPA = L] has been synthesized and utilized to prepare new Fe(III) complexes with exogenous anionic ligands, Cl ̄ and NO3 ̄ . The complexes have been characterized by IR, UV-visible, cyclic voltammetry, EPR and mass spectrometry. Low temperature EPR spectra are characteristic of a rhombic complex un...

The bonds in the five-membered ring of the title hydrated salt, C(14)H(17)N(2) (+)·Br(-)·2H(2)O, are delocalized. The cation lies on a special position of m site symmetry such that the mirror plane passes through the imidazol-yl-methyl bond and is perpendicular to the plane of the cation. The anion lies on another special position of 2 site symmetry. The anion and uncoordinated water mol-ecule ...

Easily synthesized1-methyl-3-(2-oxyethyl)-1H-imidazol-3-ium-borate sulfonic acid {[MOEI]-BSA} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1,2-dicarbonyl compounds at room temperature conditions in ethanol. This research provides a new method for the synthesis of quinoxalines in good to excellent yields with little c...

Treatment of 1-(n-butyl)-3-N-(2-Ar)acetamido-1, 3-imidazolium chloride (Ar=furylmethyl,phenylmethyl) with excess K2CO3 and [PdCl2(L−L)] (L−L=2 PPh3, dppf) afforded orange compounds composition [(1-(n-butyl)-3-N-(2-Ar)acetamido-1,3-imidazol-2-ylidene)]2Pd (Ar=furylmethyl; phenylmethyl). These complexes were characterized by NMR (1H 13C{1H} NMR), IR micro-analysis data. Subsequently, the catalyti...