Recent data suggest that the role of CYP3A4 in imatinib metabolism is smaller than presumed. This study aimed to evaluate the quantitative importance of different cytochrome P450 (P450) enzymes in imatinib pharmacokinetics. First, the metabolism of imatinib was investigated using recombinant P450 enzymes and human liver microsomes with P450 isoform-selective inhibitors. Thereafter, an in silico...

Synthesis of highly 13 C isotope enriched azafullerene, C 59 N embedded in C 60 is reported. 13 C enriched fullerenes, produced with the Krätschmer-Huffmann process, were subject to a N 2 discharge that produces C 59 N with a low probability. Raman spectroscopy indicates a homogeneous 13 C distribution. Electron spin resonance measurement (ESR) proves that the C 59 N concentration, 0.2 %, is si...

A recent result of Schmidt has brought Williamson matrices back into the spotlight. In this paper a new algorithm is introduced to search for hard to find Williamson matrices. We find all nonequivalent Williamson matrices of odd order n up to n = 59. It turns out that there are none for n = 35, 47, 53, 59 and it seems that the Turyn class may be the only infinite class of these matrices. AMS Su...

Analogies and Positive Transfer in Artificial Grammar Learning Abstract Following Brooks and Vokey (1991), we showFollowing Brooks and Vokey (1991), we show that positive transfer to new items generated from an artificial grammar in which the vocabulary has been changed from training to test can be based on “abstract analogy” to specific training items (specific similarity) rather than abstract...

Chronic pelvic pain is a common debilitating condition affecting women and presents a major challenge to healthcare providers. Laparoscopy is the only test capable of diagnosing peritoneal endometriosis and adhesions. Gynaecologists have, therefore, seen it as an essential tool in the assessment of women with chronic pelvic pain. This article explores the role of surgery in the management of ch...