Stigmatella aurantiaca displays a complex developmental life cycle in response to starvation conditions that results in the formation of tree-like fruiting bodies capable of producing spores. The phage Mx8, first isolated from the close relative Myxococcus xanthus, is unable to infect S. aurantiaca cells and integrate into the genome. However, plasmids containing Mx8 fragments encoding the inte...

An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The activity was excreted into the supernatant during the log and early stationary phase. When the organism was fermented in the presence of the adsorber resin XAD-16, the metabolite was quantitatively bound to the resin. The main component, jerangolid A, has structural similari...

Tubulysins are a group of secondary metabolites produced by myxobacteria that inhibit the function eukayotic cytoskeleton. We developed pair PCR primers specifically amplified tubulysin biosynthetic genes. Using these primers, eight out eighty-one strains belonging to Cystobacteraceae family harbored putative genes were screened through analysis. The selected included two Archangium gephyra, St...

A third group o f antibiotics, the aurachins, have been isolated from the m yxobacterium Stigmatella aurantiaca. The aurachins chemically are quinolones, and four o f them (aurachins A D ) have been tested for their inhibitory activity in photosystem II and cytochrom e b/ccomplexes. A urachin C is the best inhibitor in photosystem II (p /50-value 7.2); its biochemical behaviour being the same l...

Myxothiazol, a new antibiotic from the myxobacterium Myxococcus fulvus, inhibited the growth of many yeasts and fungi at concentrations between 0.01 and 3 micrograms/ml. It was generally inactive against bacteria. The inhibitory effect was cytostatic. With Candida albicans, Saccharomyces cerevisiae, and Mucor hiemalis, the growth inhibition was neutralized by glucose. Soon after being added to ...

Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cy...