One of the most severe and incurable forms of neurodegeneration, Alzheimer’s disease (AD), is characterized in the brain by the accumulation of aggregated amyloid-b (Ab) peptides. In the diseased brain, elevated concentrations of metals, such as Fe, Cu, and Zn, are found in Ab plaques. It has been proposed that metal ions, such as Cu and Zn, can bind to Ab ; this causes enhanced peptide aggrega...

From the needles of Taxus baccata the following flavonoids were isolated: 3-O-rutinosides quercetin, myricetin and kaempferol, 7-O-glucosides kaempferol and quercetin, kaempferol, quercetin, myricetin. The composition of flavonols and biflavones in some of the species of the genus Taxus, namely T. celebica, T. cuspidata, T. media and cultivar varieties T. baccata 'Aurea', T. baccata 'Aurea deco...

Myricetin (3, 5, 7-Trihydroxy -2(3, 4, 5-trihydroxyphenyl) 4-chromenone), a naturally occurring flavonol, is a potent scavenger of reactive oxygen species (ROS) and effectively prevent erythrocyte oxidation. The protective effect of myricetin on proteins and lipids of erythrocytes membranes was investigated. Erythrocytes membranes were subjected to oxidative stress by incubating them with 10 M ...

Foot ulceration is a major cause of morbidity in patients with diabetes, and abnormal peripheral neuropathy often results in hospitalization. Up-regulation of matrix metalloproteinases and down-regulation of tissue inhibitor of metalloproteinase 1 are noted to be distinctive biological functions of diabetic dermal fibroblasts. The aim of this study was to evaluate the biological effects of modi...

This research was carried out to evaluate the effects of flavone, myricetin, naringin, catechin, rutin, quercetin, and kaempferol at the concentration of 4.5% of the substrate (dry matter basis) on the rumen microbial activity in vitro. Mixture of guinea grass and concentrate (60 : 40) was used as the substrate. The results showed that all the flavonoids except naringin and quercetin significan...

Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous ...

Flavonoids are widely occurring in our diet. In this study, the effects of nine flavonoids on acetaminophen (APAP) oxidation and related cytochrome P450 (P450) enzyme activities were investigated. With rat liver microsomes, APAP oxidation was stimulated 2- to 4-fold by 50 microM flavone or tangeretin and inhibited 65% by myricetin or quercetin. Only a slight inhibition of APAP oxidation was cau...

Helicases couple the hydrolysis of nucleoside triphosphates (NTPs) to the unwinding of double-stranded nucleic acids and are essential in DNA metabolism. Thus far, no inhibitors are known for helicases except heliquinomycin isolated from Streptomyces sp. As the three-dimensional structure of the hexameric replicative DNA helicase RepA encoded by the broad host-range plasmid RSF1010 is known, th...

The present study evaluated the antihyperlipidemic activity of myricetin, myricetrin, the alcohol fraction (AF) and the ethyl acetate fraction (EF) obtained from the bark of Myrica rubra (MR) in high-fat and high-cholesterol (HFHC) induced hyperlipidemic C57BL/6j mice. Mice were treated with myricetin, myricetrin, AF and EF with a dose of 130 mg per kg per day for 35 days. After treatment, seru...