نتایج جستجو برای: myocardial ischemia reperfusion

تعداد نتایج: 215814  

Journal: :Physiological research 2011
H Ríha J Neckář F Papoušek I Netuka J Pirk F Kolář B Ošťádal

Inhalational anesthetic-induced preconditioning (APC) has been shown to reduce infarct size and attenuate contractile dysfunction caused by myocardial ischemia. Only a few studies have reported the effects of APC on arrhythmias during myocardial ischemia-reperfusion injury, focusing exclusively on reperfusion. Accordingly, the aim of the present study was to examine the influence of APC on vent...

Journal: :Circulation 2007
Michael Buerke Diethard Pruefer Dennis Sankat Justin M Carter Ute Buerke Martin Russ Axel Schlitt Ivar Friedrich Jochen Börgermann Christian F Vahl Karl Werdan

BACKGROUND Reperfusion injury of ischemic myocardium has been attributed to neutrophil infiltration, inflammatory activation and cardiac necrosis/apoptosis. Serine protease inhibition with aprotinin is cardioprotective, but the mechanism is unknown. METHODS AND RESULTS We studied aprotinin in a rat model of myocardial ischemia for 20 minutes and reperfusion for 20 minutes, 8 hours or 24 hours...

Journal: :physiology and pharmacology 0
fatemeh safari dept of physiology, faculty of medical sciences, tarbiat modares university, tehran sohrab hajizadeh dept of physiology, faculty of medical sciences, tarbiat modares university, tehran shahnaz shekarforush islamic azad university, arsanjan branch, fars mehdi forouzandeh dept. medical biotechnology, faculty of medical sciences, tarbiat modares university, tehran, iran mohsen foadoddini department of physiology and pharmacology, birjand university of medical sciences, birjand, iran gholamreza bayat dept of physiology, faculty of medical sciences, tarbiat modares university, tehran

introduction: inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. the aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ace) inhibitor, ramiprilat and angiotensin type 1 (at1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat model...

Journal: :Circulation 1993
X L Ma A S Weyrich D J Lefer M Buerke K H Albertine T K Kishimoto A M Lefer

BACKGROUND Interaction of CD11/CD18 located on neutrophil membranes with its endothelial counter-receptor, intercellular adhesion molecule-1, plays a major role in polymorphonuclear leukocyte (PMN)-mediated endothelial dysfunction and myocardial injury associated with ischemia and reperfusion. However, PMN-derived L-selectin, which is thought to play an early role in PMN rolling along the vascu...

Ali Khoshbaten, Ali Noroozzadeh, Fatemeh Safari, Leila Golmanesh, Shahnaz Shekarforush,

Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. This phenomenon is named remote preconditioning of trauma. Since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-...

2017
Haihui Xie Shu Zhang Zhiping Li Wei Du

The study was to evaluate the roles of Adiponectin (ADP) in alleviating myocardial ischemia-reperfusion injury in rats with Remote Ischemic Postconditioning (RIP). A total of 57 healthy male SD rats were randomly divided into 3 groups (the sham operation group (S), the myocardial ischemia-reperfusion group (I/R), and the RIP group (R). The myocardial ischemia-reperfusion injury model was establ...

Journal: :American journal of physiology. Heart and circulatory physiology 2008
Ning Zou Lihua Ao Joseph C Cleveland Xiaoping Yang Xin Su Guang-Yun Cai Anirban Banerjee David A Fullerton Xianzhong Meng

Previous studies showed that Toll-like receptor 4 (TLR4) modulates the myocardial inflammatory response to ischemia-reperfusion injury, and we recently found that cytokines link TLR4 to postischemic cardiac dysfunction. Although TLR4 can be activated in cultured cells by endogenous agents including heat shock protein 70, how it is activated during myocardial ischemia-reperfusion is unknown. In ...

Journal: :Circulation 2004
Mohit Jain Lei Cui Daniel A Brenner Bo Wang Diane E Handy Jane A Leopold Joseph Loscalzo Carl S Apstein Ronglih Liao

BACKGROUND Free radical injury contributes to cardiac dysfunction during ischemia-reperfusion. Detoxification of free radicals requires maintenance of reduced glutathione (GSH) by NADPH. The principal mechanism responsible for generating NADPH and maintaining GSH during periods of myocardial ischemia-reperfusion remains unknown. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme...

Journal: :Circulation 1999
C Csonka Z Szilvássy F Fülöp T Páli I E Blasig A Tosaki R Schulz P Ferdinandy

BACKGROUND The role of NO in the mechanism of preconditioning is not understood. Therefore, we studied the effect of preconditioning and subsequent ischemia/reperfusion on myocardial NO content in the presence of an NO synthase (NOS) inhibitor. METHODS AND RESULTS Isolated working rat hearts were subjected to preconditioning protocols of 3 intermittent periods of rapid pacing or no-flow ische...

Journal: :The Journal of biological chemistry 2003
Jiang Yang Steven P Jones Toshimitsu Suhara James J M Greer Paul D Ware Nhan P Nguyen Harris Perlman David P Nelson David J Lefer Kenneth Walsh

Fas ligand (FasL) is a member of tumor necrosis factor family that induces apoptosis in target cells that express Fas. The function of FasL during inflammation remains controversial. In this study, we examined the role of vascular endothelial FasL during acute myocardial ischemia-reperfusion that is closely associated with inflammation. Transgenic mouse lines were established that overexpress h...

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