We examined whether differences in the location of myocardial hypertrophy influence the right ventricular diastolic function in patients with non-obstructive hypertrophic cardiomyopathy using cineangiography. Biplane right ventriculography was performed in 34 subjects (normal = 14, asymmetric septal hypertrophy = 9, apical hypertrophy = 11) during cardiac catheterization. In patients with asymm...

Background Hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited disease, characterized by myocardial wall thickening in the absence of other etiologies of hypertrophy. Histologically, HCM is characterized by myocyte hypertrophy and disarray with collagen deposition. Native T1 time of the myocardium is increased in the presence of myocardial fibrosis. The purpose of this study wa...

The present study is to explore the interventional effects and potential mechanisms of Maslinic acid on heart damage in obesity hypertension. rats were given SHR high-fat diet for 16 weeks. WGA staining Masson applied detect structure fibrosis degree. WB method was used expressions ANP, BNP, P-MHC, TGF-?1, CTGF, Collagen I, III, Fibronectin other proteins tissue. ELISA serum TNF-?, IL-6, PAI-1 ...

BACKGROUND The relevance of left ventricular (LV) geometric pattern after myocardial infarction is not known. OBJECTIVES To analyze the presence of different LV geometric patterns and their impact as a predictor of remodeling in patients with myocardial infarction. METHODS Patients with anterior acute myocardial infarction (n = 80) were divided according to the geometric pattern: normal (no...

OBJECTIVES Diastolic dysfunction that determines symptoms and prognosis in patients with systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our recent studies have suggested that myocardial stiffening is likely to play a crucial role in triggering deleterious cardiac disorder. This study investigated differential contribution of left ventricular (LV) hypertro...

Although a relationship between periodontitis and myocardial hypertrophy has been reported, the precise mechanism has not been clarified. The purpose of this study was to investigate the association between periodontal infection and myocardial hypertrophy. Transverse aortic constriction (TAC) was performed. Mice were injected with Aggregatibacter actinomycetemcomitans (A.a.) (0.1 mL of 10(8) CF...

Background—The mechanisms that contribute to cardiac allograft hypertrophy are not known; however, the rapid progression and severity of hypertrophy suggest that nonhemodynamic factors may play a contributory role. Tumor necrosis factor-a (TNF-a) is a cytokine produced in cardiac allografts and capable of producing hypertrophy and fibrosis; therefore, we suggest that TNF-a may play a contributo...

Cardiac hypertrophy is a compensatory mechanism that occurs in conjunction with cardiovascular diseases. Although hypertrophy of the myocardium provides certain benefits during the early stages of cardiovascular disease, prolonged hypertrophy is potentially harmful to the heart and can result in arrhythmia and heart failure. The aim of this study was to investigate whether an ATP‑sensitive K+ (...

BACKGROUND The mechanisms that contribute to cardiac allograft hypertrophy are not known; however, the rapid progression and severity of hypertrophy suggest that nonhemodynamic factors may play a contributory role. Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced in cardiac allografts and capable of producing hypertrophy and fibrosis; therefore, we suggest that TNF-alpha may play ...

OBJECTIVE Recent observations suggest the existence of a myocardial endothelin (ET) system and its possible involvement in left-ventricular myocardial hypertrophy and failure. However, nothing is known about the role of myocardial ET in right-ventricular hypertrophy. METHODS Rats (80-100 g) were given an intraperitoneal injection of saline (controls) or monocrotaline (50 mg/kg) resulting in p...