CONTEXT Intrauterine closure of exposed spinal cord tissue prevents secondary neurologic injury in animals with a surgically created spinal defect; however, whether in utero repair of myelomeningocele improves neurologic outcome in infants with spina bifida is not known. OBJECTIVE To determine whether intrauterine repair of myelomeningocele improves patient outcomes compared with standard car...

BACKGROUND Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown. OBJECTIVES To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors. METHODS The study included 55 children a...

AIM To advance understanding of the interrelationships of sex, level of lesion (LOL), self-management, community integration (employment, independent living), and quality of life (QOL) in young adults with myelomeningocele. METHOD A multicenter convenience sample of 50 individuals with myelomeningocele, 18 to 25 years of age (mean age 21 y 5 mo, SD 2 y), participated in a structured clinical ...

Anencephaly and myelomeningocele are the 2 most common forms of neural tube defects (NTDs). During embryogenesis large numbers of extrinsic and intrinsic factors are responsible for the closing of the neural tube. "Stem cells" maintain the pluripotency during differentiation of 3 germ layers, including the neural ectoderm. We examined the role of Oct4, Nanog3, and Sox2 genes in the etiopatholog...

Peter M. DeJong, BS,a Nicholas S. Adams, MD,a,b Robert J. Mann, MD,a,b,c John W. Polley, MD,a,b,c and John A. Girotto, MD, MMAa,b,c aMichigan State University College of Human Medicine, Grand Rapids, Mich; bPlastic and Reconstructive Surgery Residency, Grand Rapids Medical Education Partners, Grand Rapids, Mich; and cPediatric Plastic and Craniofacial Surgery, Helen DeVos Children’s Hospital, G...

Objective: Neural tube defects (NTDs) are common in northern areas of Khyber Pakhtunkhwa (KPK) and need a lot community education for the parents regarding this disease, which impaired patients their whole life. The study aimed to assess contribution family history myelomeningocele resulting incidence Chiari II malformation.
 Materials Methods: A total 131 were observed determine frequency...